Core D The overall goals of the Neuropathology and Biospecimen Core are to obtain ante- and postmortem biospecimens and tissues from ADRC participants in support of research on Alzheimer disease and related disorders, to provide state-of-the art neuropathologic diagnoses for center participants, and report Core data to the NACC. The special emphasis of our Core lies in the integration of classical neuropathology with systems biology and advanced clinical and imaging studies. This emphasis guided the selection of Dr. Tony Wyss- Coray (a neurobiologist with a background in neuroimmunity, proteomics, and Alzheimer disease biomarkers) as the Core Leader and Dr. Edward Plowey (a neuropathologist trained in cutting-edge diagnostic techniques and neurodegeneration research as a neuropathology fellow with the University of Pittsburgh ADRC) as the Core co-leader and director of the Stanford ADRC brain bank. The core also benefits from the experience and track record of a previously funded Alzheimer's Disease Core Center at Stanford University and the Palo Alto VA from 2000 to 2009 during which time 57 autopsy cases were collected and 43 submitted to NACC. Tissues from these cases will be made available for distribution under the new core with the assistance of Dr. Ahmad Salehi, director of the brain bank at the VA. As part of the proposed focus on neuro-immune interactions and novel genomics approaches, cerebrospinal fluid, plasma, blood, and skin biopsies will be collected for proteomic, genomic, and cellular measurements, which will be made available upon request as part of the resources provided by the Core. The Neuropathology and Biospecimen Core will closely collaborate with the Administrative, Clinical, Imaging, and Data Management and Biostatistics Cores to optimize the use of these biospecimens by investigators at Stanford, other Alzheimer's Disease Centers, and other qualified institutions.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Specialized Center (P50)
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Special Emphasis Panel (ZAG1)
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Stanford University
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Haaksma, Miriam L; Calderón-Larrañaga, Amaia; Olde Rikkert, Marcel G M et al. (2018) Cognitive and functional progression in Alzheimer disease: A prediction model of latent classes. Int J Geriatr Psychiatry 33:1057-1064
Smith, Alexander K; Periyakoil, Vyjeyanthi S (2018) Should We Bury ""The Good Death""? J Am Geriatr Soc 66:856-858
Ramsey, Christine M; Gnjidic, Danijela; Agogo, George O et al. (2018) Longitudinal patterns of potentially inappropriate medication use following incident dementia diagnosis. Alzheimers Dement (N Y) 4:1-10
Hadjichrysanthou, Christoforos; McRae-McKee, Kevin; Evans, Stephanie et al. (2018) Potential Factors Associated with Cognitive Improvement of Individuals Diagnosed with Mild Cognitive Impairment or Dementia in Longitudinal Studies. J Alzheimers Dis 66:587-600
Hanfelt, John J; Peng, Limin; Goldstein, Felicia C et al. (2018) Latent classes of mild cognitive impairment are associated with clinical outcomes and neuropathology: Analysis of data from the National Alzheimer's Coordinating Center. Neurobiol Dis 117:62-71
Burke, Shanna L; Hu, Tianyan; Fava, Nicole M et al. (2018) Sex differences in the development of mild cognitive impairment and probable Alzheimer's disease as predicted by hippocampal volume or white matter hyperintensities. J Women Aging :1-25
Harvey, Zachary H; Chen, Yiwen; Jarosz, Daniel F (2018) Protein-Based Inheritance: Epigenetics beyond the Chromosome. Mol Cell 69:195-202
Wang, Qi; Guo, Lei; Thompson, Paul M et al. (2018) The Added Value of Diffusion-Weighted MRI-Derived Structural Connectome in Evaluating Mild Cognitive Impairment: A Multi-Cohort Validation1. J Alzheimers Dis 64:149-169
Wang, Tingyan; Qiu, Robin G; Yu, Ming (2018) Predictive Modeling of the Progression of Alzheimer's Disease with Recurrent Neural Networks. Sci Rep 8:9161
Clark, Jennie Leeder; Phoenix, Sarah; Bilbrey, Ann Choryan et al. (2018) Cultural Competency in Dementia Care: An African American Case Study. Clin Gerontol 41:255-260

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