A center for immunologic research in disease is proposed which will use recently developed techniques for the study of mediators from mast cells and basophils to explore a variety of allergic and inflammatory conditions. Individual projects propose to study: 1. Mediator release in inflammatory bowel disease, 2. Proteases in bullous pemphigoid and chronic urticaria, 3. Mechanisms of anti-inflammatory actions of corticosteroids, 4. The production and modulation of arachidonic acid metabolites by purified human lung mast cells and macrophages, 5. The pathogenesis and treatment of allergic rhinitis and non-allergic rhinitis, 6. Regulation of acute airways reactions in lung disease including asthma, 7. Natural history of insect allergy, 8. Cyclooxygenase metabolites in human lung anaphylaxis, 9. Macrophages and immunologically mediated inflammation, 10. Effect of medical intervention of social and emotional cost of insect sting allergy in children, 11. Prevalence of sub-optimal immunotherapy for aeroallergen disease.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Specialized Center (P50)
Project #
5P50AI020136-07
Application #
3105052
Study Section
(SRC)
Project Start
1983-09-01
Project End
1991-08-31
Budget Start
1989-09-01
Budget End
1990-08-31
Support Year
7
Fiscal Year
1989
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Type
Schools of Medicine
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Peters, S P; Lichtenstein, L M; Adkinson Jr, N F (1986) Mediator release from human lung under conditions of reduced oxygen tension. J Pharmacol Exp Ther 238:8-13
Peters, S P; Tung, R S; Chatham, M et al. (1985) Inhibitability and enhanceability of basophil histamine release in asthmatic and normal subjects. Int Arch Allergy Appl Immunol 76:344-9