Reactions and Metabolism of Immune Proteins and Cells

Rosen, Fred S.

Abstract

This program is a multidisciplinary approach to the study of the immunopathogenesis of immunodeficiency disease, allergic states, graft-versus-host disease following bone marrow transplantation and collagen disease, particularly lupus erythematosus. B cell lines from immunodeficient patients will be studied for expression of Ig genes. T and B cells from patients with the Wiskott-Aldrich syndrome will be examined to understand the molecular basis of the glycophorin (gp 115) deficiency. The cellular basis of natural tolerance will be studied in congenic mice who are C5 deficient or C5 sufficient. The surface antigens of T cells of mice and man that are involved in lymphocyte toxicity will be defined by monoclonal antibodies. Control of Ia expression on murine and human macrophages will be investigated.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Allergy and Infectious Diseases (NIAID)
• Type: Specialized Center (P50)
• Project #: 5P50AI021163-08
• Application #: 3105067
• Study Section: Allergy, Immunology, and Transplantation Research Committee (AITC)
• Project Start: 1983-01-01
• Project End: 1991-08-31
• Budget Start: 1989-09-01
• Budget End: 1990-08-31
• Support Year: 8
• Fiscal Year: 1989

Institution

• Name: Children's Hospital Boston
• DUNS #: 076593722
• City: Boston
• State: MA
• Country: United States
• Zip Code: 02115

Publications

Castigli, E; Chatila, T A; Geha, R S (1993) A protein of the AP-1 family is a component of nuclear factor of activated T cells. J Immunol 150:3284-90

Spertini, F; Chatila, T; Geha, R S (1992) Signals delivered via MHC class II molecules synergize with signals delivered via TCR/CD3 to cause proliferation and cytokine gene expression in T cells. J Immunol 149:65-70

Spertini, F; Spits, H; Geha, R S (1991) Staphylococcal exotoxins deliver activation signals to human T-cell clones via major histocompatibility complex class II molecules. Proc Natl Acad Sci U S A 88:7533-7

Scholl, P R; Sekaly, R P; Diez, A et al. (1990) Binding of toxic shock syndrome toxin-1 to murine major histocompatibility complex class II molecules. Eur J Immunol 20:1911-6

Scholl, P R; Diez, A; Karr, R et al. (1990) Effect of isotypes and allelic polymorphism on the binding of staphylococcal exotoxins to MHC class II molecules. J Immunol 144:226-30

Silk, H; Geha, R S (1988) Asthma, recurrent infections and IgG2 deficiency. Ann Allergy 60:98, 134-6

Hemler, M E; Jacobson, J G; Brenner, M B et al. (1985) VLA-1: a T cell surface antigen which defines a novel late stage of human T cell activation. Eur J Immunol 15:502-8