Abstract

The main theme of this asthma and allergic disease center application is focussed on immunoregulation and interaction between cells participating in immunologic and/or inflammatory responses. Most of the investigators involved in this work have a background well founded in immunology, have developed and/or are using in vitro models to study immunologic reactions, and are applying the new information to patients with allergic and hypersensitivity diseases. An example of how we are approaching this problem is presented in the first project in which the effect of immunotherapy in cat-induced asthmatics is being investigated. In this project, several facets of immune function as well as the clinical benefit derived from immunotherapy is being evaluated.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Specialized Center (P50)
Project #
2P50AI024848-02A1
Application #
3105087
Study Section
Allergy, Immunology, and Transplantation Research Committee (AITC)
Project Start
1987-09-01
Project End
1989-08-31
Budget Start
1988-09-01
Budget End
1989-08-31
Support Year
2
Fiscal Year
1988
Total Cost
Indirect Cost

  Institution

Name
Tufts University
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02111

  Publications

Xiang, Shi-Hua; Finzi, Andrés; Pacheco, Beatriz et al. (2010) A V3 loop-dependent gp120 element disrupted by CD4 binding stabilizes the human immunodeficiency virus envelope glycoprotein trimer. J Virol 84:3147-61
Borish, L; Mascali, J J; Klinnert, M et al. (1994) SSC polymorphisms in interleukin genes. Hum Mol Genet 3:1710
Matz, J; Williams, J; Rosenwasser, L J et al. (1994) Granulocyte-macrophage colony-stimulating factor stimulates macrophages to respond to IgE via the low affinity IgE receptor (CD23). J Allergy Clin Immunol 93:650-7
Ohman Jr, J L; Sparrow, D; MacDonald, M R (1993) New onset wheezing in an older male population: evidence of allergen sensitization in a longitudinal study. Results of the normative aging study. J Allergy Clin Immunol 91:752-7
Joseph, B Z; Routes, J M; Borish, L (1993) Activities of superoxide dismutases and NADPH oxidase in neutrophils obtained from asthmatic and normal donors. Inflammation 17:361-70
Borish, L; Dishuck, J; Cox, L et al. (1993) Sezary syndrome with elevated serum IgE and hypereosinophilia: role of dysregulated cytokine production. J Allergy Clin Immunol 92:123-31
Williams, J; Johnson, S; Mascali, J J et al. (1992) Regulation of low affinity IgE receptor (CD23) expression on mononuclear phagocytes in normal and asthmatic subjects. J Immunol 149:2823-9
Joseph, B Z; Sustiel, A M; Borish, L (1992) Neutrophils from asthmatics exhibit diminished responsiveness to 2-chloroadenosine which is reversed by theophylline. Evidence for a cyclic-AMP-independent pathway on human neutrophils. Inflammation 16:101-16
Borish, L; King, M S; Mascali, J J et al. (1992) Transthyretin is an inhibitor of monocyte and endothelial cell interleukin-1 production. Inflammation 16:471-84
Borish, L; Williams, J; Johnson, S et al. (1992) Anti-inflammatory effects of nedocromil sodium: inhibition of alveolar macrophage function. Clin Exp Allergy 22:984-90

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