Abstract

Cells which are components of allergic inflammation bear on their surfaces or contain proteins which subserve specific functions, and understanding these functions wlil permit control of the allergic process. Three overlapping themes are identified: (1) the function of receptors on neutrophils, including the IgG Fc-gamma receptors (subproject 1, Dr. Ruddy) and the F-met-leu-phe receptor (subproject 2, Dr. Freer); (2) mechanisms of induction, regulation and maintenance of IgE synthesis, including the roles of follicular dendritic cells and antibody feedback (subproject 3, Dr. Tew) and the role of IgE and/or IgE immune complexes in lymphocyte activation (subproject 5, Dr. Schwartz) and the regulation of mast cell genesis (Dr. Huff).

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Specialized Center (P50)
Project #
5P50AI028532-04
Application #
3105106
Study Section
Allergy & Clinical Immunology-1 (AITC)
Project Start
1989-08-01
Project End
1993-09-30
Budget Start
1992-08-01
Budget End
1993-09-30
Support Year
4
Fiscal Year
1992
Total Cost
Indirect Cost

  Institution

Name
Virginia Commonwealth University
Department
Type
Schools of Medicine
DUNS #
City
Richmond
State
VA
Country
United States
Zip Code
23298

  Publications

Lantz, C S; Huff, T F (1995) Differential responsiveness of purified mouse c-kit+ mast cells and their progenitors to IL-3 and stem cell factor. J Immunol 155:4024-9
Ryan, J J; Klein, K A; Neuberger, T J et al. (1994) Role for the stem cell factor/KIT complex in Schwann cell neoplasia and mast cell proliferation associated with neurofibromatosis. J Neurosci Res 37:415-32
Leftwich, J A; Westin, E H; Huff, T F (1992) Expression of c-kit by mesenteric lymph node cells from Nippostrongylus brasiliensis-infected mice and by mast cell colonies developing from these cells in response to 3T3 fibroblast-conditioned medium. J Immunol 148:2894-8
Maeda, K; Burton, G F; Padgett, D A et al. (1992) Murine follicular dendritic cells and low affinity Fc receptors for IgE (Fc epsilon RII). J Immunol 148:2340-7
Tew, J G; DiLosa, R M; Burton, G F et al. (1992) Germinal centers and antibody production in bone marrow. Immunol Rev 126:99-112
Catlett, J P; Leftwich, J A; Westin, E H et al. (1991) c-kit expression by CD34+ bone marrow progenitors and inhibition of response to recombinant human interleukin-3 following exposure to c-kit antisense oligonucleotides. Blood 78:3186-91
Ashman, R I; Jarboe, D L; Conrad, D H et al. (1991) The mast cell-committed progenitor. In vitro generation of committed progenitors from bone marrow. J Immunol 146:211-6
Kermode, J C; Freer, R J; Becker, E L (1991) The significance of functional receptor heterogeneity in the biological responses of the rabbit neutrophil to stimulation by chemotactic formyl peptides. Biochem J 276 ( Pt 3):715-23
Tew, J G; Kosco, M H; Burton, G F et al. (1990) Follicular dendritic cells as accessory cells. Immunol Rev 117:185-211