This core facility will serve all three projects by providing a center of excellence in molecular biology and biotechnology for the Institute of Parasitic Diseases (IPD). Through common space, large equipment, and trained expertise in applying diverse molecular tools we will greatly augment the molecular systematic medical malacology and parasitology component at the I.P.D. The proposed Core will become the premier Molecular Parasitology and Parasite Biotechnology resource center for all China. Specifically we propose: 1) To study molecular genetics and divergence of targeted populations of parasites and snail hosts using modern techniques in molecular biology and biotechnology. Genetic divergence will be examined through the analysis of genetic markers using allozymes, restriction fragment length polymorphisms (RFLPs), and DNA sequencing of targeted genes. The focus here will be to uncover the degree of genetic convergence and phylogeny among populations of parasites and their snail vectors previously thought to comprise the same species, and by implication, genetically uniform; 2) To catalogue the genetic diversity within the three helminth groups and their snail vectors through the construction of genomic and cDNA libraries; 3) To provide the computer- mediated analytic capabilities to assess the molecular taxonomic data collected in specific aims 1 and 2; 4) To develop novel molecular transfection systems for targeted vaccine delivery.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Specialized Center (P50)
Project #
Application #
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
National Institute of Parasitic Diseases
Zip Code
Schrader, Matthias; Hauffe, Torsten; Zhang, Zhijie et al. (2013) Spatially explicit modeling of schistosomiasis risk in eastern China based on a synthesis of epidemiological, environmental and intermediate host genetic data. PLoS Negl Trop Dis 7:e2327
Schistosoma japonicum Genome Sequencing and Functional Analysis Consortium (2009) The Schistosoma japonicum genome reveals features of host-parasite interplay. Nature 460:345-51
Yin, Mingbo; Hu, Wei; Mo, Xiaojin et al. (2008) Multiple near-identical genotypes of Schistosoma japonicum can occur in snails and have implications for population-genetic analyses. Int J Parasitol 38:1681-91
Ellis, Magda K; Raso, Giovanna; Li, Yue-Sheng et al. (2007) Familial aggregation of human susceptibility to co- and multiple helminth infections in a population from the Poyang Lake region, China. Int J Parasitol 37:1153-61
Ellis, Magda K; Zhao, Zhen Zhen; Chen, Hong-Gen et al. (2007) Analysis of the 5q31 33 locus shows an association between single nucleotide polymorphism variants in the IL-5 gene and symptomatic infection with the human blood fluke, Schistosoma japonicum. J Immunol 179:8366-71
Wang, Lili; Yang, Zhong; Li, Yuanyuan et al. (2006) Reconstruction and in silico analysis of the MAPK signaling pathways in the human blood fluke, Schistosoma japonicum. FEBS Lett 580:3677-86
Ellis, Magda K; Li, Yuesheng; Rong, Zhu et al. (2006) Familial aggregation of human infection with Schistosoma japonicum in the Poyang Lake region, China. Int J Parasitol 36:71-7
Guo, Jiagang; Li, Yuesheng; Gray, Darren et al. (2006) A drug-based intervention study on the importance of buffaloes for human Schistosoma japonicum infection around Poyang Lake, People's Republic of China. Am J Trop Med Hyg 74:335-41
Liu, Feng; Lu, Jiong; Hu, Wei et al. (2006) New perspectives on host-parasite interplay by comparative transcriptomic and proteomic analyses of Schistosoma japonicum. PLoS Pathog 2:e29
McManus, D P (2005) Prospects for development of a transmission blocking vaccine against Schistosoma japonicum. Parasite Immunol 27:297-308

Showing the most recent 10 out of 56 publications