The TMRC proposal aims at establishing a research program on Leishmaniaisis at Institut Pasteur de Tunis (IPT), Tunis;Tunisia. The TMRC will benefit of dedicated spaces and laboratories and will be daily managed by an administrative core under the supervision of the Program Director. The TMRC administrative Core (TAG) will be responsible for managing, coordinating and supervising the entire range of TMRC activities, monitoring progress and insuring that the overall management plan in implemented effectively and within proposed times lines. A full time administrative manager will be hired by the project to run the activities of the TAC. She/he will have identified responsibilities and tasks and will serve as an active interface between the TMRC and the IPT administration. The later will be responsible of the realization of the tasks at the request of the TAC (recruitment, purchase, salary payment, importation of goods, account auditing relations with banks etc... A steering committee chaired by the PD will comprise the project Pis', the Data Manager and Administrative Manager and will meet once a month to review the current activities and solve any difficulty that could emerge.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Specialized Center (P50)
Project #
5P50AI074178-05
Application #
8321824
Study Section
Special Emphasis Panel (ZAI1)
Project Start
Project End
2013-07-31
Budget Start
2011-08-01
Budget End
2012-07-31
Support Year
5
Fiscal Year
2011
Total Cost
$26,612
Indirect Cost
Name
Institute Pasteur de Tunis
Department
Type
DUNS #
499250553
City
Tunis
State
Country
Tunisia
Zip Code
1002
Ghouila, Amel; Guerfali, Fatma Z; Atri, Chiraz et al. (2017) Comparative genomics of Tunisian Leishmania major isolates causing human cutaneous leishmaniasis with contrasting clinical severity. Infect Genet Evol 50:110-120
Kammoun-Rebai, Wafa; Naouar, Ikbel; Libri, Valentina et al. (2016) Protein biomarkers discriminate Leishmania major-infected and non-infected individuals in areas endemic for cutaneous leishmaniasis. BMC Infect Dis 16:138
Naouar, Ikbel; Boussoffara, Thouraya; Chenik, Mehdi et al. (2016) Prediction of T Cell Epitopes from Leishmania major Potentially Excreted/Secreted Proteins Inducing Granzyme B Production. PLoS One 11:e0147076
Marzouki, Soumaya; Kammoun-Rebai, Wafa; Bettaieb, Jihene et al. (2015) Validation of Recombinant Salivary Protein PpSP32 as a Suitable Marker of Human Exposure to Phlebotomus papatasi, the Vector of Leishmania major in Tunisia. PLoS Negl Trop Dis 9:e0003991
Harrabi, Myriam; Bettaieb, Jihène; Ghawar, Wissem et al. (2015) Spatio-temporal Genetic Structuring of Leishmania major in Tunisia by Microsatellite Analysis. PLoS Negl Trop Dis 9:e0004017
Bettaieb, Jihene; Toumi, Amine; Chlif, Sadok et al. (2014) Prevalence and determinants of Leishmania major infection in emerging and old foci in Tunisia. Parasit Vectors 7:386
Kharrat, Nadia; Aissa, Imen; Sghaier, Manel et al. (2014) Lipophilization of ascorbic acid: a monolayer study and biological and antileishmanial activities. J Agric Food Chem 62:9118-27
Ghawar, Wissem; Attia, Hanène; Bettaieb, Jihene et al. (2014) Genotype profile of Leishmania major strains isolated from tunisian rodent reservoir hosts revealed by multilocus microsatellite typing. PLoS One 9:e107043
Naouar, Ikbel; Boussoffara, Thouraya; Ben Ahmed, Melika et al. (2014) Involvement of different CD4(+) T cell subsets producing granzyme B in the immune response to Leishmania major antigens. Mediators Inflamm 2014:636039
Lemaire, Julien; Mkannez, Ghada; Guerfali, Fatma Z et al. (2013) MicroRNA expression profile in human macrophages in response to Leishmania major infection. PLoS Negl Trop Dis 7:e2478

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