Properly developed and managed electronic databases are key requirements for research and web-based data warehouses and tools are particularly important for multidisciplinary groups to keep track of study data from different sources. Analytical expertise underpins the ability of this project to provide new insights into Chagas disease biomarkers. The Database and Biostatistics Core will develop and maintain a Research Database (RD) that will compile the clinical and laboratory data collected by the SAMI-Trop project and monitor data quality. The RD will have a modular architecture to allow for data entry and access for each project and sub-projects, as well as intregation of findings from all projects. A secure access study website will allow for data sharing process, will support epidemiological synthesis and statistical analysis of the information collected, and will faciliate dissemination of the findings of the program;

Public Health Relevance

The Database and Biostatistics Core will be critical to support the development of comprehensive research databases that will be generated by the SAMI-Trop projects. The Core will also develop a secure access study website for data sharing, support epidemiological synthesis and statistical analyses, and faciliate dissemination of the findings of the program;.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Specialized Center (P50)
Project #
5P50AI098461-04
Application #
8890095
Study Section
Special Emphasis Panel (ZAI1)
Project Start
Project End
Budget Start
2015-08-01
Budget End
2016-07-31
Support Year
4
Fiscal Year
2015
Total Cost
Indirect Cost
Name
Fundacao Faculdade de Medicina
Department
Type
DUNS #
902096528
City
Sao Paulo
State
Country
Brazil
Zip Code
05401-000
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Ferreira, Ludmila Rodrigues Pinto; Ferreira, Frederico Moraes; Nakaya, Helder Imoto et al. (2017) Blood Gene Signatures of Chagas Cardiomyopathy With or Without Ventricular Dysfunction. J Infect Dis 215:387-395
Capuani, Ligia; Bierrenbach, Ana Luiza; Pereira Alencar, Airlane et al. (2017) Mortality among blood donors seropositive and seronegative for Chagas disease (1996-2000) in São Paulo, Brazil: A death certificate linkage study. PLoS Negl Trop Dis 11:e0005542
Ferreira, Ariela Mota; Sabino, Ester Cerdeira; de Oliveira, Lea Campos et al. (2016) Benznidazole Use among Patients with Chronic Chagas' Cardiomyopathy in an Endemic Region of Brazil. PLoS One 11:e0165950
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Navarro, Isabela Cunha; Ferreira, Frederico Moraes; Nakaya, Helder I et al. (2015) MicroRNA Transcriptome Profiling in Heart of Trypanosoma cruzi-Infected Mice: Parasitological and Cardiological Outcomes. PLoS Negl Trop Dis 9:e0003828
Carmo, Andre A L; Rocha, Manoel O C; Silva, Jose L P et al. (2015) Amiodarone and Trypanosoma cruzi parasitemia in patients with Chagas disease. Int J Cardiol 189:182-4
Capuani, Ligia; Bierrenbach, Ana Luiza; Abreu, Fatima et al. (2014) Accuracy of a probabilistic record-linkage methodology used to track blood donors in the Mortality Information System database. Cad Saude Publica 30:1623-32

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