This is a Program Project application for a Specialized Center of Research in Osteoporosis to be established at Creighton University manned by 4 experienced investigators. The theme of the Center is research into the etiology, prevention and treatment of osteoporosis. The 7 projects in this proposal will join 9 other current or pending projects. The projects are; 1) Family Studies in Osteoporosis, which will characterize the inheritance of osteoporosis, something which has not previously been accomplished. 2) Bone Histomorphometry Before and After Menopause which, will characterize the changes in bone cell function that underlie the rapid loss of bone occurring in humans immediately after menopause. 3) Nutrition and Bone Loss after Ovariectomy which will be a study of the ovariectomized rat as a model of trabecular bone loss, and the influence of dietary manipulations on that loss. 4) Identification and Treatment of Calcium Deficiency which will attempt to find a method of identifying dietary calcium deficiency in otherwise healthy women, and test whether giving calcium to these persons will inhibit bone loss. 5) Calcium Bioavailability from Certain Plant Sources, which will determine the extent to which oxalate and phytate interfere with calcium absorption, and assess calcium absorbability from several plant foods. 6) Restoration of Bone Mass by """"""""Coherence"""""""" Treatment, which will be a trial of a method of restoring lost bone by activating remodeling sites, suppressing their resorptive activity, and then allowing bone formation to overfill the shallow resorption cavities, creating new trabecular bone. 7) Effect of a Strength Training Program on Bone Density, which will be a test of whether strength training of the muscles of the spine and hip will increase bone mass at these sites. These projects will advance the understanding of osteoporosis, and will bring us closer to reducing the morbidity and mortality associated with this condition which afflicts nearly half of our elderly population.

National Institute of Health (NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Specialized Center (P50)
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Arthritis and Musculoskeletal and Skin Diseases Special Grants Review Committee (AMS)
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Creighton University
Schools of Medicine
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Recker, Robert; Lappe, Joan; Davies, K Michael et al. (2004) Bone remodeling increases substantially in the years after menopause and remains increased in older osteoporosis patients. J Bone Miner Res 19:1628-33
Paschalis, E P; Recker, R; DiCarlo, E et al. (2003) Distribution of collagen cross-links in normal human trabecular bone. J Bone Miner Res 18:1942-6
Heaney, Robert P (2003) Normalizing calcium intake: projected population effects for body weight. J Nutr 133:268S-270S
Samnegard, E; Akhter, M P; Recker, R R (2001) Maintenance of vertebral body bone mass and strength created by human parathyroid hormone treatment in ovariectomized rats. Bone 28:414-22
Iwaniec, U T; Samnegard, E; Cullen, D M et al. (2001) Maintenance of cancellous bone in ovariectomized, human parathyroid hormone [hPTH(1-84)]-treated rats by estrogen, risedronate, or reduced hPTH. Bone 29:352-60
Cullen, D M; Smith, R T; Akhter, M P (2001) Bone-loading response varies with strain magnitude and cycle number. J Appl Physiol 91:1971-6
Davies, K M; Heaney, R P; Recker, R R et al. (2001) Hormones, weight change and menopause. Int J Obes Relat Metab Disord 25:874-9
Samnegard, E; Iwaniec, U T; Cullen, D M et al. (2001) Maintenance of cortical bone in human parathyroid hormone(1-84)-treated ovariectomized rats. Bone 28:251-60
Samnegard, E; Cullen, D M; Akhter, M P et al. (2001) No effect of verapamil on the local bone response to in vivo mechanical loading. J Orthop Res 19:328-36
Cullen, D M; Smith, R T; Akhter, M P (2000) Time course for bone formation with long-term external mechanical loading. J Appl Physiol 88:1943-8

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