Abstract

The Morphology/Ultrastructure Core Facility will serve all investigators of the SCOR grant who need histological, histochemical, and ultrastructural analyses of biological specimens. This Core will provide expertise in the following areas of morphological tissue analyses: (1) Processing of tissues for routine histology (paraffin embedding; routine staining procedures); (2) Processing or tissues and cells for specialized histochemical analyses (live or fixed tissues and cells); (3) Processing of tissues or cultured cells for routine transmission and scanning electron microscopic analyses (fixation, plastic embedding; thick- and thin-sectioning; uranyl acetate/lead staining; critical point drying; thin-layer sputtering, etc.); and (4) Processing of tissues or cells for specialized, ultrastructural- histochemical analyses (e.g., GAG histochemistry; Immuno- Electron Microscopy; etc). The Morphology/Ultrastructure Core will also provide expertise in the areas of photography and quantitative ultrastructural analyses (Stereology).

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Specialized Center (P50)
Project #
3P50AR039239-05S1
Application #
3792146
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
5
Fiscal Year
1992
Total Cost
Indirect Cost

  Institution

Name
Rush University Medical Center
Department
Type
DUNS #
City
Chicago
State
IL
Country
United States
Zip Code
60612

  Publications

Knudson, Warren; Ishizuka, Shinya; Terabe, Kenya et al. (2018) The pericellular hyaluronan of articular chondrocytes. Matrix Biol :
Tezcan, Mehmet E; Goker, Berna; Lidtke, Roy et al. (2017) Long-term effects of lateral wedge orthotics on hip and ankle joint space widths. Gait Posture 51:36-40
Patchigolla, R Krishna R; Knudson, Warren; Schmid, Thomas M (2012) Matrix metalloproteinase-9 in a unique proteoglycan form in avian embryonic growth plate cartilage. Arch Biochem Biophys 520:42-50
Anderson, Donald D; Chubinskaya, Susan; Guilak, Farshid et al. (2011) Post-traumatic osteoarthritis: improved understanding and opportunities for early intervention. J Orthop Res 29:802-9
Rolauffs, Bernd; Williams, James M; Aurich, Matthias et al. (2010) Proliferative remodeling of the spatial organization of human superficial chondrocytes distant from focal early osteoarthritis. Arthritis Rheum 62:489-98
Farlow, Erin C; Patel, Kalpa; Basu, Sanjib et al. (2010) Development of a multiplexed tumor-associated autoantibody-based blood test for the detection of non-small cell lung cancer. Clin Cancer Res 16:3452-62
Schmitz, I; Ariyoshi, W; Takahashi, N et al. (2010) Hyaluronan oligosaccharide treatment of chondrocytes stimulates expression of both HAS-2 and MMP-3, but by different signaling pathways. Osteoarthritis Cartilage 18:447-54
Bajaj, Sarvottam; Shoemaker, Thomas; Hakimiyan, Arnavaz A et al. (2010) Protective effect of P188 in the model of acute trauma to human ankle cartilage: the mechanism of action. J Orthop Trauma 24:571-6
Morris, Kirsten J; Cs-Szabo, Gabriella; Cole, Ada A (2010) Characterization of TIMP-3 in human articular talar cartilage. Connect Tissue Res 51:478-90
Rolauffs, Bernd; Muehleman, Carol; Li, Jun et al. (2010) Vulnerability of the superficial zone of immature articular cartilage to compressive injury. Arthritis Rheum 62:3016-27

Showing the most recent 10 out of 305 publications