Abstract

The primary goal of this SCOR is to understand how human rheumatoid synovium is maintained in its chronic inflammatory state. This new information will help SCOR investigators propose and develop novel therapeutic interventions. To support these studies, a Research Resources Core will be created to help organize the collection of human clinical material as well as provide specialized support for the in vivo studies involving animal models of arthritis. The project requires human synovial tissue specimens, synovial mononuclear cells, or synovial fluid from patients with established and early rheumatoid arthritis (RA). One purpose of this core is to develop an implement an efficient, timely, and centralized mechanism for the acquisition and distribution of these research materials. Animal models of rheumatoid arthritis have also been used extensively to study the pathogenesis of chronic inflammatory arthritis. Proper conduct and evaluation of these animal models requires specialized expertise to ensure reliable and interpretable results. Therefore, the Core will help coordinate and centralize the efforts of the investigators and provide ready access to experienced investigators in animal models of arthritis.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Specialized Center (P50)
Project #
5P50AR044850-03
Application #
6352674
Study Section
Project Start
2000-09-01
Project End
2001-08-31
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
3
Fiscal Year
2000
Total Cost
$196,912
Indirect Cost

  Institution

Name
University of California San Diego
Department
Type
DUNS #
077758407
City
La Jolla
State
CA
Country
United States
Zip Code
92093

  Publications

Wu, Christina C N; Hayashi, Tomoko; Takabayashi, Kenji et al. (2007) Immunotherapeutic activity of a conjugate of a Toll-like receptor 7 ligand. Proc Natl Acad Sci U S A 104:3990-5
Albani, Salvatore; Prakken, Berent (2006) T cell epitope-specific immune therapy for rheumatic diseases. Arthritis Rheum 54:19-25
Giannoni, Francesca; Barnett, Joellen; Bi, Kun et al. (2005) Clustering of T cell ligands on artificial APC membranes influences T cell activation and protein kinase C theta translocation to the T cell plasma membrane. J Immunol 174:3204-11
Holderbaum, D; Malvitz, T; Ciesielski, C J et al. (2005) A newly described hereditary cartilage debonding syndrome. Arthritis Rheum 52:3300-4
Prakken, Berent J; Samodal, Rodrigo; Le, Tho D et al. (2004) Epitope-specific immunotherapy induces immune deviation of proinflammatory T cells in rheumatoid arthritis. Proc Natl Acad Sci U S A 101:4228-33
de Kleer, Isme M; Wedderburn, Lucy R; Taams, Leonie S et al. (2004) CD4+CD25bright regulatory T cells actively regulate inflammation in the joints of patients with the remitting form of juvenile idiopathic arthritis. J Immunol 172:6435-43
Lu, Desheng; Zhao, Yandong; Tawatao, Rommel et al. (2004) Activation of the Wnt signaling pathway in chronic lymphocytic leukemia. Proc Natl Acad Sci U S A 101:3118-23
Sen, Malini; Cheng, Yu-Ho; Goldring, Mary B et al. (2004) WISP3-dependent regulation of type II collagen and aggrecan production in chondrocytes. Arthritis Rheum 50:488-97
Wu, Christina C N; Lee, Jongdae; Raz, Eyal et al. (2004) Necessity of oligonucleotide aggregation for toll-like receptor 9 activation. J Biol Chem 279:33071-8
Leake, John A D; Albani, Salvatore; Kao, Annie S et al. (2004) Acute disseminated encephalomyelitis in childhood: epidemiologic, clinical and laboratory features. Pediatr Infect Dis J 23:756-64

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