Successful orthopaedic management of displaced intra-articular fractures, to forestall post-traumatic osteoarthritis (OA), depends on avoidance of a mechanical environment that is deleterious to articular cartilage. Clinically, there are many reports of cases or series where patients have done surprisingly well in the presence of substantial incongruency, provided that joint stability is maintained, whereas minimally displaced or congruously repaired intra-articular fractures often fare poorly in the presence of joint instability. To date, almost no attention has been directed to the causative mechanisms by which instability induces post-traumatic OA. Many confounding factors, especially heterogeneity of injury, preclude systematic human clinical study of the relative importance of instability versus incongruency as causes of osteoarthritis secondary to intra-articular fractures. We propose laboratory studies, to investigate mechanisms of how global joint instability manifests itself in terms of mechanical anomaly at the tissue and cellular level, where osteoarthritis metabolically originates. And, we propose to study how local incongruity and global instability interact in that regard.
Three specific aims will be pursued. First, in an established cadaver model of stepoff tibial plafond fracture, we will measure transient intra-articular contact stresses under quasi-physiologic loading throughout plantar-dorsiflexion cycles, for meta(stable) versus unstable articulations. Second, using a contact finite element model of a tibial plafond fracture stepoff incongruity that incorporates a (rate-dependent) poroelastic constitutive formulation for cartilage, we will compute internal cartilage stresses for loading and motion inputs spanning the instant of transition of transition from (meta)stable to unstable articulation. Third, in an established rabbit knee defect model, we modulate instability by means of partial sectionings of the anterior cruciate ligament, and document the speed/severity of the resulting secondary degenerative changes. If dynamic instability can be shown to be a more potent determinant of post-traumatic OA following intra-articular fractures than is chronically elevated contract, this would strongly argue that orthopaedic management of these difficult injuries ought to prioritize attaining suitable thresholds of joint stability, rather than the presently dominant strategy of aggressive interventions to attain precise congruency in order to minimize contact stress elevations.

National Institute of Health (NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
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University of Iowa
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Martin, James A; Anderson, Donald D; Goetz, Jessica E et al. (2017) Complementary models reveal cellular responses to contact stresses that contribute to post-traumatic osteoarthritis. J Orthop Res 35:515-523
Kempton, Laurence B; Dibbern, Kevin; Anderson, Donald D et al. (2016) Objective Metric of Energy Absorbed in Tibial Plateau Fractures Corresponds Well to Clinician Assessment of Fracture Severity. J Orthop Trauma 30:551-6
Anderson, Donald D; Kilburg, Anthony T; Thomas, Thaddeus P et al. (2016) Expedited CT-Based Methods for Evaluating Fracture Severity to Assess Risk of Post-Traumatic Osteoarthritis After Articular Fractures. Iowa Orthop J 36:46-52
Anderson, Donald D; Long, Steven; Thomas, Geb W et al. (2016) Objective Structured Assessments of Technical Skills (OSATS) Does Not Assess the Quality of the Surgical Result Effectively. Clin Orthop Relat Res 474:874-81
Kern, Andrew M; Anderson, Donald D (2015) Expedited patient-specific assessment of contact stress exposure in the ankle joint following definitive articular fracture reduction. J Biomech 48:3427-32
Nguyen, Mai P; Pedersen, Douglas R; Gao, Yubo et al. (2015) Intermediate-term follow-up after ankle distraction for treatment of end-stage osteoarthritis. J Bone Joint Surg Am 97:590-6
Anderson, Donald D; Thomas, Thaddeus P; Campos Marin, Ana et al. (2014) Computational techniques for the assessment of fracture repair. Injury 45 Suppl 2:S23-31
Buckwalter, Joseph A; Anderson, Donald D; Brown, Thomas D et al. (2013) The Roles of Mechanical Stresses in the Pathogenesis of Osteoarthritis: Implications for Treatment of Joint Injuries. Cartilage 4:286-294
Sauter, Ellen; Buckwalter, Joseph A; McKinley, Todd O et al. (2012) Cytoskeletal dissolution blocks oxidant release and cell death in injured cartilage. J Orthop Res 30:593-8
Saltzman, Charles L; Hillis, Stephen L; Stolley, Mary P et al. (2012) Motion versus fixed distraction of the joint in the treatment of ankle osteoarthritis: a prospective randomized controlled trial. J Bone Joint Surg Am 94:961-70

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