The Administrative and Biostatistics Core will serve all four translational research projects and the tworesearch cores. It will be under the direction of Dr. Joseph Buckwalter (CORT Program Director). Dr.Buckwalter, working with Dr. Thomas Brown (Associate CORT Program Director), will provide overalladministrative direction and coordination of all projects and cores. He will also be responsible for facilitatinginteraction between projects and investigators and in particular interactions between bioengineers, basicscientists, experts in imaging, and orthopaedic surgeons. He will promote and facilitate the translation ofbasic and bioengineering research to patient-based studies and stimulate new basic research based on theresults of the clinical studies. Should the need arise; Dr. Thomas Brown will assume the responsibilities ofthe program director. The CORT Advisory Group includes Martha Gray, Ph.D. (an expert in study anddevelopment of new methods of joint imaging), Walter Herzog, Ph.D. and Jack Lewis, Ph.D. (experiencedbiomechanists with expertise in the study of joint injury and joint mechanics), Stefan Lohmander, M.D.,Ph.D. (an orthopaedic surgeon who has conducted critical studies of joint injuries and post-traumaticosteoarthritis) and Carol Vorwald, R.N. (a lay person with long standing interest in patients withosteoarthritis). Dr. Brown and Dr. Buckwalter will work closely together to make effective use of the CORTAdvisory Group and the Enrichment Program. They will also administer the Data Sharing Plan and theProgram for Pilot and Feasibility Projects. Lois Lembke, Administrative Assistant II in the Department ofOrthopaedics and Rehabilitation, has extensive experience in administrating grants and departmentalprograms. She will assist Dr. Buckwalter with the day-to-day administrative details, program coordination,and planning an evaluation of the program. Her involvement will facilitate supervision and management ofthe CORT unit and the individual project budgets. Dr. Stephen L. Hillis, Senior Biostatician of the Center forResearch in the Implementation of Innovative Strategies in Practice (CRIIISP) at the Iowa City VA MedicalCenter, has provided detailed consultation and direction for the development of all research projects withinthe CORT. He will be continually involved in all projects and responsible for experimental design issues,monitoring of data collection, and statistical analysis for all projects.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Specialized Center (P50)
Project #
1P50AR055533-01
Application #
7347200
Study Section
Special Emphasis Panel (ZAR1-MLB-G (O1))
Project Start
2007-09-10
Project End
2012-08-31
Budget Start
2007-09-10
Budget End
2008-08-31
Support Year
1
Fiscal Year
2007
Total Cost
$151,869
Indirect Cost
Name
University of Iowa
Department
Type
DUNS #
062761671
City
Iowa City
State
IA
Country
United States
Zip Code
52242
Seol, Dongrim; Tochigi, Yuki; Bogner, Ashley M et al. (2018) Effects of knockout of the receptor for advanced glycation end-products on bone mineral density and synovitis in mice with intra-articular fractures. J Orthop Res 36:2439-2449
Thomas-Aitken, Holly D; Willey, Michael C; Goetz, Jessica E (2018) Joint contact stresses calculated for acetabular dysplasia patients using discrete element analysis are significantly influenced by the applied gait pattern. J Biomech 79:45-53
Coleman, Mitchell C; Goetz, Jessica E; Brouillette, Marc J et al. (2018) Targeting mitochondrial responses to intra-articular fracture to prevent posttraumatic osteoarthritis. Sci Transl Med 10:
Townsend, Kevin C; Thomas-Aitken, Holly D; Rudert, M James et al. (2018) Discrete element analysis is a valid method for computing joint contact stress in the hip before and after acetabular fracture. J Biomech 67:9-17
Ding, Lei; Buckwalter, Joseph A; Martin, James A (2017) DAMPs Synergize with Cytokines or Fibronectin Fragment on Inducing Chondrolysis but Lose Effect When Acting Alone. Mediators Inflamm 2017:2642549
Segal, Neil A; Frick, Eric; Duryea, Jeffrey et al. (2017) Comparison of tibiofemoral joint space width measurements from standing CT and fixed flexion radiography. J Orthop Res 35:1388-1395
Segal, Neil A; Bergin, John; Kern, Andrew et al. (2017) Test-retest reliability of tibiofemoral joint space width measurements made using a low-dose standing CT scanner. Skeletal Radiol 46:217-222
Dibbern, Kevin; Kempton, Laurence B; Higgins, Thomas F et al. (2017) Fractures of the tibial plateau involve similar energies as the tibial pilon but greater articular surface involvement. J Orthop Res 35:618-624
Kapitanov, Georgi I; Ayati, Bruce P; Martin, James A (2017) Modeling the effect of blunt impact on mitochondrial function in cartilage: implications for development of osteoarthritis. PeerJ 5:e3468
Martin, James A; Anderson, Donald D; Goetz, Jessica E et al. (2017) Complementary models reveal cellular responses to contact stresses that contribute to post-traumatic osteoarthritis. J Orthop Res 35:515-523

Showing the most recent 10 out of 99 publications