The Administrative and Biostatistics Core will serve all four translational research projects and the tworesearch cores. It will be under the direction of Dr. Joseph Buckwalter (CORT Program Director). Dr.Buckwalter, working with Dr. Thomas Brown (Associate CORT Program Director), will provide overalladministrative direction and coordination of all projects and cores. He will also be responsible for facilitatinginteraction between projects and investigators and in particular interactions between bioengineers, basicscientists, experts in imaging, and orthopaedic surgeons. He will promote and facilitate the translation ofbasic and bioengineering research to patient-based studies and stimulate new basic research based on theresults of the clinical studies. Should the need arise; Dr. Thomas Brown will assume the responsibilities ofthe program director. The CORT Advisory Group includes Martha Gray, Ph.D. (an expert in study anddevelopment of new methods of joint imaging), Walter Herzog, Ph.D. and Jack Lewis, Ph.D. (experiencedbiomechanists with expertise in the study of joint injury and joint mechanics), Stefan Lohmander, M.D.,Ph.D. (an orthopaedic surgeon who has conducted critical studies of joint injuries and post-traumaticosteoarthritis) and Carol Vorwald, R.N. (a lay person with long standing interest in patients withosteoarthritis). Dr. Brown and Dr. Buckwalter will work closely together to make effective use of the CORTAdvisory Group and the Enrichment Program. They will also administer the Data Sharing Plan and theProgram for Pilot and Feasibility Projects. Lois Lembke, Administrative Assistant II in the Department ofOrthopaedics and Rehabilitation, has extensive experience in administrating grants and departmentalprograms. She will assist Dr. Buckwalter with the day-to-day administrative details, program coordination,and planning an evaluation of the program. Her involvement will facilitate supervision and management ofthe CORT unit and the individual project budgets. Dr. Stephen L. Hillis, Senior Biostatician of the Center forResearch in the Implementation of Innovative Strategies in Practice (CRIIISP) at the Iowa City VA MedicalCenter, has provided detailed consultation and direction for the development of all research projects withinthe CORT. He will be continually involved in all projects and responsible for experimental design issues,monitoring of data collection, and statistical analysis for all projects.

National Institute of Health (NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Specialized Center (P50)
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Special Emphasis Panel (ZAR1-MLB-G (O1))
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University of Iowa
Iowa City
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Seol, Dongrim; Tochigi, Yuki; Bogner, Ashley M et al. (2018) Effects of knockout of the receptor for advanced glycation end-products on bone mineral density and synovitis in mice with intra-articular fractures. J Orthop Res 36:2439-2449
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