Abstract

Biomechanics and Imaging Core The Biomechanics and Imaging Core, under the direction of Dr. Thomas D. Brown, will serve all four projects. This core unit will be primarily located in the Department of Orthopaedics and Rehabilitation's Biomechanics Laboratory. The computational stress analysis, most of the physical testing for all projects, and a substantial portion of the image analysis work will be performed in this unit. In addition, the six faculty and staff PhD bioengineers in the Biomechanics Laboratory will participate in all CORT meetings and reviews. This core has a series of general capabilities in the area of macroscopic physical testing, image analysis, and computational mechanics. In addition, it has special capabilities, developed in conjunction with the ongoing SCOR work, which will be brought to bear in support of the individual CORT projects. These include areas such as nonlinear/poroelastic finite element analysis, cartilage impaction and indentation, a multiaxial loading bioreactor, comminution energy and soft tissue injury imaging assessments, and automated quantitative cartilage histomorphometry. Individuals associated with this laboratory also are key personnel in all four of the CORT projects.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Specialized Center (P50)
Project #
5P50AR055533-03
Application #
7920170
Study Section
Special Emphasis Panel (ZAR1)
Project Start
2009-09-01
Project End
2012-08-31
Budget Start
2009-09-01
Budget End
2010-08-31
Support Year
3
Fiscal Year
2009
Total Cost
$395,200
Indirect Cost

  Institution

Name
University of Iowa
Department
Type
DUNS #
062761671
City
Iowa City
State
IA
Country
United States
Zip Code
52242

  Publications

Seol, Dongrim; Tochigi, Yuki; Bogner, Ashley M et al. (2018) Effects of knockout of the receptor for advanced glycation end-products on bone mineral density and synovitis in mice with intra-articular fractures. J Orthop Res 36:2439-2449
Thomas-Aitken, Holly D; Willey, Michael C; Goetz, Jessica E (2018) Joint contact stresses calculated for acetabular dysplasia patients using discrete element analysis are significantly influenced by the applied gait pattern. J Biomech 79:45-53
Coleman, Mitchell C; Goetz, Jessica E; Brouillette, Marc J et al. (2018) Targeting mitochondrial responses to intra-articular fracture to prevent posttraumatic osteoarthritis. Sci Transl Med 10:
Townsend, Kevin C; Thomas-Aitken, Holly D; Rudert, M James et al. (2018) Discrete element analysis is a valid method for computing joint contact stress in the hip before and after acetabular fracture. J Biomech 67:9-17
Ding, Lei; Buckwalter, Joseph A; Martin, James A (2017) DAMPs Synergize with Cytokines or Fibronectin Fragment on Inducing Chondrolysis but Lose Effect When Acting Alone. Mediators Inflamm 2017:2642549
Segal, Neil A; Frick, Eric; Duryea, Jeffrey et al. (2017) Comparison of tibiofemoral joint space width measurements from standing CT and fixed flexion radiography. J Orthop Res 35:1388-1395
Segal, Neil A; Bergin, John; Kern, Andrew et al. (2017) Test-retest reliability of tibiofemoral joint space width measurements made using a low-dose standing CT scanner. Skeletal Radiol 46:217-222
Dibbern, Kevin; Kempton, Laurence B; Higgins, Thomas F et al. (2017) Fractures of the tibial plateau involve similar energies as the tibial pilon but greater articular surface involvement. J Orthop Res 35:618-624
Kapitanov, Georgi I; Ayati, Bruce P; Martin, James A (2017) Modeling the effect of blunt impact on mitochondrial function in cartilage: implications for development of osteoarthritis. PeerJ 5:e3468
Martin, James A; Anderson, Donald D; Goetz, Jessica E et al. (2017) Complementary models reveal cellular responses to contact stresses that contribute to post-traumatic osteoarthritis. J Orthop Res 35:515-523

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