Abstract

Biomechanics and Imaging Core The Biomechanics and Imaging Core, under the direction of Dr. Thomas D. Brown, will serve all four projects. This core unit will be primarily located in the Department of Orthopaedics and Rehabilitation's Biomechanics Laboratory. The computational stress analysis, most of the physical testing for all projects, and a substantial portion of the image analysis work will be performed in this unit. In addition, the six faculty and staff PhD bioengineers in the Biomechanics Laboratory will participate in all CORT meetings and reviews. This core has a series of general capabilities in the area of macroscopic physical testing, image analysis, and computational mechanics. In addition, it has special capabilities, developed in conjunction with the ongoing SCOR work, which will be brought to bear in support of the individual CORT projects. These include areas such as nonlinear/poroelastic finite element analysis, cartilage impaction and indentation, a multiaxial loading bioreactor, comminution energy and soft tissue injury imaging assessments, and automated quantitative cartilage histomorphometry. Individuals associated with this laboratory also are key personnel in all four of the CORT projects.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Specialized Center (P50)
Project #
5P50AR055533-04
Application #
8128419
Study Section
Special Emphasis Panel (ZAR1)
Project Start
Project End
Budget Start
2010-09-01
Budget End
2011-08-31
Support Year
4
Fiscal Year
2010
Total Cost
$469,794
Indirect Cost

  Institution

Name
University of Iowa
Department
Type
DUNS #
062761671
City
Iowa City
State
IA
Country
United States
Zip Code
52242

  Publications

Seol, Dongrim; Tochigi, Yuki; Bogner, Ashley M et al. (2018) Effects of knockout of the receptor for advanced glycation end-products on bone mineral density and synovitis in mice with intra-articular fractures. J Orthop Res 36:2439-2449
Thomas-Aitken, Holly D; Willey, Michael C; Goetz, Jessica E (2018) Joint contact stresses calculated for acetabular dysplasia patients using discrete element analysis are significantly influenced by the applied gait pattern. J Biomech 79:45-53
Coleman, Mitchell C; Goetz, Jessica E; Brouillette, Marc J et al. (2018) Targeting mitochondrial responses to intra-articular fracture to prevent posttraumatic osteoarthritis. Sci Transl Med 10:
Townsend, Kevin C; Thomas-Aitken, Holly D; Rudert, M James et al. (2018) Discrete element analysis is a valid method for computing joint contact stress in the hip before and after acetabular fracture. J Biomech 67:9-17
Baer, Thomas; Frisbie, Ryan; Willey, Michael et al. (2017) Development of a Simplified Ankle Distractor. 2017 Des Med Devices Conf (2017) 2017:
Pedersen, Douglas R; El-Khoury, Georges Y; Thedens, Dan R et al. (2017) Bone contusion progression from traumatic knee injury: association of rate of contusion resolution with injury severity. Open Access J Sports Med 8:9-15
Heckelsmiller, David J; James Rudert, M; Baer, Thomas E et al. (2017) Changes in Joint Contact Mechanics in a Large Quadrupedal Animal Model After Partial Meniscectomy and a Focal Cartilage Injury. J Biomech Eng 139:
Ding, Lei; Buckwalter, Joseph A; Martin, James A (2017) DAMPs Synergize with Cytokines or Fibronectin Fragment on Inducing Chondrolysis but Lose Effect When Acting Alone. Mediators Inflamm 2017:2642549
Segal, Neil A; Frick, Eric; Duryea, Jeffrey et al. (2017) Comparison of tibiofemoral joint space width measurements from standing CT and fixed flexion radiography. J Orthop Res 35:1388-1395
Segal, Neil A; Bergin, John; Kern, Andrew et al. (2017) Test-retest reliability of tibiofemoral joint space width measurements made using a low-dose standing CT scanner. Skeletal Radiol 46:217-222

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