The Administrative, Biostatistics, and Investigator Support Core, directed by Drs. Joseph Buckwalter and Thomas Brown (CORT Program Director and Associate Director, respectively), will serve the three research projects and two research cores. Drs. Buckwalter and Brown will give the CORT direction, by coordinating all of the projects; they will also monitor budgets and ensure that investigators comply with University and NIH policies. They are committed to fostering interactions between projects and investigators, and between CORT bioengineers, basic scientists, imaging experts, and orthopaedic surgeons. A central goal for the Directors will be to spur translation of advances in basic science and bioengineering into advances in clinical treatments; reciprocally, the results of clinical studies will spur new basic research. The CORT investigators will consult with The University of Iowa Institute for Clinical and Translational Science (ICTS); Director, Gary Rosenthal MD, Associate Director for Biostatistics, Bridget Zimmerman PhD, to ensure their experimental designs meet rigorous biostatistical standards. The ICTS will support all projects and assist with performing statistical analysis, designing experiments, evaluating data collection, and submitting IRB applications so CORT repositories can collect biological specimens (e.g. joint fluid and serum). The Core will ensure that the External and Internal Advisory groups provide consultation and formally evaluate projects and cores, and identify underperforming endeavors as well as important new research directions. The CORT External and Internal Advisory Groups include internationally recognized experts: External Advisory Group?Michael Conzemius, DVIVI, PhD (veterinary medicine and animal models of OA); Christopher Evans, PhD (animal models of arthritis, gene therapy, translational research); Jack Lewis, PhD (bioengineering, OA, joint injury and joint mechanics); Stefan Lohmander MD, PhD (joint injuries, biomarkers, clinical studies and posttraumatic OA); Martin Lotz, MD (joint biology, osteoarthritis, biologic treatments of OA), and Carol Vorwald, RN (layperson and retired nurse with longstanding commitment to OA patients); Internal Advisory Group? Beverly Davidson, PhD (gene therapy), Joseph Reinhardt, PhD (imaging), and Douglas Spitz, PhD (free radical biology). Drs. Buckwalter and Brown will use the CORT Enrichment Program effectively and administer the Data-Sharing Plan and the Program for Pilot and Feasibility Projects. Lois Lembke (Administrative Assistant) has extensive experience administrating grants and departmental programs. She will assist Dr. Buckwalter with CORT administrative details, program coordination, budget monitoring, and evaluations of the projects and cores.

Public Health Relevance

The Administrative; Biostatistics and Investigator Support Core and the CORT Advisory Groups will provide oversight for the research projects and cores; solicit and evaluate new pilot and feasibility projects and stimulate development of new research directions.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Specialized Center (P50)
Project #
4P50AR055533-10
Application #
9133273
Study Section
Special Emphasis Panel (ZAR1-KM)
Project Start
Project End
Budget Start
2016-09-01
Budget End
2017-06-30
Support Year
10
Fiscal Year
2016
Total Cost
$117,324
Indirect Cost
$39,626
Name
University of Iowa
Department
Type
DUNS #
062761671
City
Iowa City
State
IA
Country
United States
Zip Code
52246
Seol, Dongrim; Tochigi, Yuki; Bogner, Ashley M et al. (2018) Effects of knockout of the receptor for advanced glycation end-products on bone mineral density and synovitis in mice with intra-articular fractures. J Orthop Res 36:2439-2449
Thomas-Aitken, Holly D; Willey, Michael C; Goetz, Jessica E (2018) Joint contact stresses calculated for acetabular dysplasia patients using discrete element analysis are significantly influenced by the applied gait pattern. J Biomech 79:45-53
Coleman, Mitchell C; Goetz, Jessica E; Brouillette, Marc J et al. (2018) Targeting mitochondrial responses to intra-articular fracture to prevent posttraumatic osteoarthritis. Sci Transl Med 10:
Townsend, Kevin C; Thomas-Aitken, Holly D; Rudert, M James et al. (2018) Discrete element analysis is a valid method for computing joint contact stress in the hip before and after acetabular fracture. J Biomech 67:9-17
Martin, James A; Anderson, Donald D; Goetz, Jessica E et al. (2017) Complementary models reveal cellular responses to contact stresses that contribute to post-traumatic osteoarthritis. J Orthop Res 35:515-523
Freeman, Katie; Michalson, Jared L; Anderson, Donald D et al. (2017) Tibial Plateau Fractures: A New Rank Ordering Method For Determining To What Degree Injury Severity Or Quality Of Reduction Correlate With Clinical Outcome. Iowa Orthop J 37:57-63
Ayati, Bruce P; Kapitanov, Georgi I; Coleman, Mitchell C et al. (2017) Mathematics as a conduit for translational research in post-traumatic osteoarthritis. J Orthop Res 35:566-572
Wang, S; Zhou, C; Zheng, H et al. (2017) Chondrogenic progenitor cells promote vascular endothelial growth factor expression through stromal-derived factor-1. Osteoarthritis Cartilage 25:742-749
Seol, Dongrim; Zhou, Cheng; Brouillette, Marc J et al. (2017) Characteristics of meniscus progenitor cells migrated from injured meniscus. J Orthop Res 35:1966-1972
Goetz, Jessica E; Coleman, Mitchell C; Fredericks, Douglas C et al. (2017) Time-dependent loss of mitochondrial function precedes progressive histologic cartilage degeneration in a rabbit meniscal destabilization model. J Orthop Res 35:590-599

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