Lateral compartment knee tibio-femoral radiographic osteoarthritis (TFROA) is associated with pain and disability, and studies of this form of knee OA are few. Recent studies find that race, pelvic anatomy and malalignment are associated with TFROA. Previous studies of knee OA have either combined medial and lateral compartment TFROA or have focused on medial compartment disease. We intend to elucidate the risk factors for and health outcomes of lateral compartment TFROA. Specifically we will (1) examine the association of lesions detected by MRI with lateral compartment TFROA;(2) examine known risk factors for medial compartment OA and their relation to prevalent and incident lateral compartment TFROA;(3) examine novel risk factors (e.g., hip and knee shape) that likely have compartment-specific effects and their relation to prevalent and incident lateral compartment TFROA;(4) examine the association of lateral compartment TFROA with incident functional impairment. We will use information collected in the Osteoarthritis Initiative (OAI) including longitudinal knee and hip x-ray and 3.0 Tesla MRI scans as well as detailed repeated risk factor, pain, and outcomes data. This proposed study will be one of the first done in a large, well-defined cohort with excellent follow-up, imaging and data collection of known and potential risk factors to focus specifically on lateral compartment TFROA.

Public Health Relevance

This research will examine the risk factors and health outcomes for a subset of knee osteoarthritis that is the lateral compartment of the knee using magnetic resonance imaging and regular x-rays. This will provide a greater understanding of the causes of functional impairment in this type of knee osteoarthritis and the progression to end stage of this disease. This will help to identify osteoarthritis patients who would be most likely to progress and to become disabled so that an effective treatment plan ca.0 be put into place to improve outcomes.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Specialized Center (P50)
Project #
5P50AR060752-04
Application #
8712114
Study Section
Special Emphasis Panel (ZAR1-KM)
Project Start
Project End
Budget Start
2014-08-01
Budget End
2015-07-31
Support Year
4
Fiscal Year
2014
Total Cost
$239,650
Indirect Cost
Name
University of California San Francisco
Department
Type
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Samaan, Michael A; Pedoia, Valentina; Zhang, Alan L et al. (2018) A novel mr-based method for detection of cartilage delamination in femoroacetabular impingement patients. J Orthop Res 36:971-978
Hofmann, Felix C; Neumann, Jan; Heilmeier, Ursula et al. (2018) Conservatively treated knee injury is associated with knee cartilage matrix degeneration measured with MRI-based T2 relaxation times: data from the osteoarthritis initiative. Skeletal Radiol 47:93-106
Pedoia, Valentina; Samaan, Michael A; Inamdar, Gaurav et al. (2018) Study of the interactions between proximal femur 3d bone shape, cartilage health, and biomechanics in patients with hip Osteoarthritis. J Orthop Res 36:330-341
Teng, Hsiang-Ling; Pedoia, Valentina; Link, Thomas M et al. (2018) Local associations between knee cartilage T1? and T2 relaxation times and patellofemoral joint stress during walking: A voxel-based relaxometry analysis. Knee 25:406-416
Pedoia, Valentina; Haefeli, Jenny; Morioka, Kazuhito et al. (2018) MRI and biomechanics multidimensional data analysis reveals R2 -R1? as an early predictor of cartilage lesion progression in knee osteoarthritis. J Magn Reson Imaging 47:78-90
Bolcos, Paul O; Mononen, Mika E; Mohammadi, Ali et al. (2018) Comparison between kinetic and kinetic-kinematic driven knee joint finite element models. Sci Rep 8:17351
Lansdown, Drew; Ma, Chunbong Benjamin (2018) The Influence of Tibial and Femoral Bone Morphology on Knee Kinematics in the Anterior Cruciate Ligament Injured Knee. Clin Sports Med 37:127-136
Schwaiger, Benedikt J; Mbapte Wamba, John; Gersing, Alexandra S et al. (2018) Hyperintense signal alteration in the suprapatellar fat pad on MRI is associated with degeneration of the patellofemoral joint over 48 months: data from the Osteoarthritis Initiative. Skeletal Radiol 47:329-339
Kumar, Deepak; Wyatt, Cory; Lee, Sonia et al. (2018) Sagittal plane walking patterns are related to MRI changes over 18-months in people with and without mild-moderate hip osteoarthritis. J Orthop Res 36:1472-1477
Shimizu, Tomohiro; Samaan, Michael A; Tanaka, Matthew S et al. (2018) Abnormal Biomechanics at 6 Months Are Associated With Cartilage Degeneration at 3 Years After Anterior Cruciate Ligament Reconstruction. Arthroscopy :

Showing the most recent 10 out of 150 publications