The major objective of the Administrative Core is to focus the efforts of the UAB CORT in Gout and Hyperuricemia on four specific research projects. Our theme is 'Gout and Hyperuricemia: from Bench to Bedside to Backyard'. We propose a multi-disciplinary approach to type 1 (T1) and type 2 (T2) translational research projects that present significant opportunities for advancement of l<nowledge in four major research areas relevant to gout and hyperuricemia: 1) Genetics of gout, 2) Hyperuricemia and cardiovascular outcomes, 3) Evidence implementation, effectiveness, and safety of gout therapies in large populations. The four projects are further united by a subtheme of racial/ethnic disparities in gout and hyperuricemia. The overall goal for our UAB CORT is to improve the healthcare of patients with gout and hyperuricemia by applying scientifically rigorous, state-of-the-art methodology to clinically important questions in translational research. The specific objectives of the UAB CORT's Administrative Core are to assure the CORT has the organizational oversight and institutional resources to: 1. Conduct outstanding, innovative research projects drawing on the unique strengths of the UAB Comprehensive Arthritis Musculoskeletal, and Autoimmunity Center (CAMAC), along with other relevant University-wide Interdisciplinary Research Centers and academic units (e.g. the UAB Division of Clinical Immunology and Rheumatology) using state-of-the-art tools from genetics and pharmacogenetics, biostatistics, epidemiology, clinical trials design, and outcomes research. 2. Foster the development of Development and Feasibility projects and the development and application of new evaluative, analytic, and translational methods to research in gout and hyperuricemia; and, 3. Through an enrichment program, promote the training of clinical investigators in the most current methods of translational research applicable to gout and hyperuricemia. The Administrative Core will coordinate the UAB CORT's activities while facilitating interactions and collaborations, promoting scientific development, performing continuous evaluation of ongoing UAB CORT programs, and setting the strategic agenda for the UAB CORT. A major responsibility of the Administrative Core is to focus the resources of the Institution on the CORT, its investigators, and its specific research projects. The strong research resources, robust institutional commitment, and an experienced, multi- disciplinary, highly energetic and focused team of investigators predict a high likelihood of success.

Public Health Relevance

Gout and high serum urate levels are common. Our CORT in Gout; aimed at improving the care of patients with gout; will be overseen by an Administrative core. This Core will assure that scientifically rigorous; state- of-the-art methodology is applied to clinically important questions in translational research.

National Institute of Health (NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Specialized Center (P50)
Project #
Application #
Study Section
Special Emphasis Panel (ZAR1-KM)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Alabama Birmingham
United States
Zip Code
Ryan, Evan M; Duryee, Michael J; Hollins, Andrew et al. (2018) Antioxidant properties of citric acid interfere with the uricase-based measurement of circulating uric acid. J Pharm Biomed Anal 164:460-466
Melles, Ronald B; Jorge, April M; Marmor, Michael F et al. (2018) Sharp decline in hydroxychloroquine dosing-analysis of 17,797 initiators from 2007 to 2016. Clin Rheumatol 37:1853-1859
Bursill, David; Taylor, William J; Terkeltaub, Robert et al. (2018) Gout, Hyperuricemia and Crystal-Associated Disease Network (G-CAN) consensus statement regarding labels and definitions for disease elements in gout. Arthritis Care Res (Hoboken) :
Jorge, April; Wallace, Zachary S; Zhang, Yuqing et al. (2018) All-Cause and Cause-Specific Mortality Trends of End-Stage Renal Disease due to Lupus Nephritis from 1995 to 2014. Arthritis Rheumatol :
Choi, Hyon; Neogi, Tuhina; Stamp, Lisa et al. (2018) New Perspectives in Rheumatology: Implications of the Cardiovascular Safety of Febuxostat and Allopurinol in Patients With Gout and Cardiovascular Morbidities Trial and the Associated Food and Drug Administration Public Safety Alert. Arthritis Rheumatol 70:1702-1709
McWherter, Charles; Choi, Yun-Jung; Serrano, Ramon L et al. (2018) Arhalofenate acid inhibits monosodium urate crystal-induced inflammatory responses through activation of AMP-activated protein kinase (AMPK) signaling. Arthritis Res Ther 20:204
Sun, Mengying; Vazquez, Ana I; Reynolds, Richard J et al. (2018) Untangling the complex relationships between incident gout risk, serum urate, and its comorbidities. Arthritis Res Ther 20:90
Mikuls, Ted R; Cheetham, T Craig; Levy, Gerald D et al. (2018) A Pharmacist-Led Intervention to Improve Gout Medication Adherence and Outcomes with Urate Lowering Therapy: A Site Randomized Trial. Am J Med :
Johnson, Tate M; Register, Kyle A; Schmidt, Cynthia M et al. (2018) Correlation of the Multi-Biomarker Disease Activity Score with Rheumatoid Arthritis Disease Activity Measures: A Systematic Review and Meta-Analysis. Arthritis Care Res (Hoboken) :
England, Bryant R; Thiele, Geoffrey M; Anderson, Daniel R et al. (2018) Increased cardiovascular risk in rheumatoid arthritis: mechanisms and implications. BMJ 361:k1036

Showing the most recent 10 out of 57 publications