Spinal deformity has an important and measurable impact on physical function and health-related quality of life (HRQoL), particularly in older adults. Deformity in the sagittal plane has the largest impact on clinical health status of older adults, increasing pain, and compromising gait speed, functional reach, balance, self- image, and satisfacfion with life in general. Hyperkyphosis is an important cause of sagittal plane malalignment and has been associated with poor health outcomes, including falls, fractures, activities of daily living (ADL) disability, and mortality. Higher prevalence of hyperkyphosis has been reported.among females versus males, 28% versus 14%, respectively. Hyperkyphosis is accompanied by spinal muscle weakness17- 19 that may be modifiable with exercise. Sex differences in muscle strength may differentially affect the severity of hyperkyhosis and modify the response to exercise. Currently, there are few evidence-based treatments targeted to reduce hyperkyhosis and no proven exercise interventions that reduce hyperkyphosis and delay funcfional decline and disability. The primary hypothesis of project IV is that interventions that reduce hyperkyphosis by improving spinal muscle strength will also delay functional decline and disability, and could, therefore, have significant public health benefits. No study examining the impact of exercise to improve hyperkyphosis has determined whether treatment effects differ according to sex. This project proposes a paradigm where physical function can be improved in an exercise intervention targeted at reducing hyperkyphosis, which may reduce associated disability. Pilot work conducted by the project research team suggests that the approach is feasible and potentially effective. Project IV proposes a randomized controlled trial comparing a 12-week high-intensity spinal strengthening exercise intervenfion and home exercise pracfice to a control stretching intervenfion in community-dwelling males and females 55- 80 years old with hyperkyphosis. All primary and secondary outcomes will be compared between the exercise and the control group after 12-weeks. The long-term goal is to develop intervenfions to delay funcfional decline and physical disability in older males and females and to identify those who would most benefit from interventions.

Public Health Relevance

Exercise intervenfions targeted at increasing funcfion in older adults often neglect posture and spinal muscle weakness. No study examining the impact of exercise to improve hyperkyphosis has determined whether treatment effects differ according to sex. The aims of Project IV propose a paradigm where physical function can be improved in an exercise intervention targeted at reducing hyperkyphosis, which may reduce associated disability.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Specialized Center (P50)
Project #
5P50AR063043-03
Application #
8734224
Study Section
Special Emphasis Panel (ZRG1)
Project Start
2014-09-01
Project End
2017-08-31
Budget Start
2014-09-01
Budget End
2015-08-31
Support Year
3
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of California Davis
Department
Type
DUNS #
City
Davis
State
CA
Country
United States
Zip Code
95618
Landsman, Victoria; Fillery, Mark; Vernon, Howard et al. (2018) Sample size calculations for blinding assessment. J Biopharm Stat 28:857-869
Tran, Tuan A; Williams, Lisa M; Bui, Donna et al. (2018) Prospective Pilot Study Comparing Pre- and Postsurgical CTSAQ and Neuro-QoL Questionnaire with Median Nerve High-Resolution Ultrasound Cross-Sectional Areas. J Hand Surg Am 43:184.e1-184.e9
Roghani, Taybeh; Khalkhali Zavieh, Minoo; Rahimi, Abbas et al. (2018) The reliability and validity of a designed setup for the assessment of static back extensor force and endurance in older women with and without hyperkyphosis. Physiother Theory Pract 34:882-893
Wise, Barton L; Niu, Jingbo; Zhang, Yuqing et al. (2018) Bone shape mediates the relationship between sex and incident knee osteoarthritis. BMC Musculoskelet Disord 19:331
Orwoll, Eric S; Wiedrick, Jack; Jacobs, Jon et al. (2018) High-throughput serum proteomics for the identification of protein biomarkers of mortality in older men. Aging Cell 17:
Rogers, Tara S; Harrison, Stephanie; Swanson, Christine et al. (2017) Rest-activity circadian rhythms and bone mineral density in elderly men. Bone Rep 7:156-163
Zhang, Hongliang; Kot, Alexander; Lay, Yu-An E et al. (2017) Acceleration of Fracture Healing by Overexpression of Basic Fibroblast Growth Factor in the Mesenchymal Stromal Cells. Stem Cells Transl Med 6:1880-1893
Kot, Alexander; Zhong, Zhendong A; Zhang, Hongliang et al. (2017) Sex dimorphic regulation of osteoprogenitor progesterone in bone stromal cells. J Mol Endocrinol 59:351-363
Zhong, Zhendong A; Kot, Alexander; Lay, Yu-An E et al. (2017) Sex-Dependent, Osteoblast Stage-Specific Effects of Progesterone Receptor on Bone Acquisition. J Bone Miner Res 32:1841-1852
Katzman, Wendy B; Huang, Mei-Hua; Kritz-Silverstein, Donna et al. (2017) Diffuse Idiopathic Skeletal Hyperostosis (DISH) and Impaired Physical Function: The Rancho Bernardo Study. J Am Geriatr Soc 65:1476-1481

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