Incidence and prevalence of either radiographic or symptomatic osteoarthritis (OA) are much higher in women than men; however, the underlying causes for this sex difference in OA remain unknown. Several potential explanations have been proposed for the sex difference in OA, including differences in estrogen level, physical activity, and laxity or alignment, but each has only moderate supporting evidence, and none fully explains the observed sex differences. Recently, several investigators have proposed that aspects of bone shape are associated with an increased risk of incident OA and with severity of OA, based on anthropometric measures, cross-sectional findings, or in one case statistical shape modeling done on 24 knees. Our group demonstrated that several specific proximal femoral shapes, assessed by Active Shape Modeling (ASM), were associated with incident radiographic hip OA in elderly women. Others have also reported that ASM-based knee shape is associated with severity of radiographic knee OA. It is postulated that changes in bone shape occur prior to cartilage damage in the joint. In the proposed study, we will take the advantage of knee radiographs and magnetic resonance images (MRIs) collected annually for 5 years in the Osteoarthritis Initiative (OAI). We will measure femoral and tibial bone shape using an ASM method improved by our group. We will evaluate whether baseline bone shape is associated with incidence or progression of radiographic knee OA, pain and function and whether these associations differ by sex. We will apply group-based finite modeling methods to identify distinctive sub-groups that follow similar trajectories of bone shape change over time in women and men respectively and examine whether associations between various risk factors assessed at baseline (i.e., age, sex, body mass index, alignment, etc.) and membership of trajectories of bone shape differ by sex using a multinomial logistic regression model. Finally, we will evaluate the risk factors that determine sex-specific trajectories of bone shape change over time.

Public Health Relevance

To our knowledge, no study has yet described the trajectories of changes in bone shape over time, examined how those trajectories differ by sex, or identified the risk factors that determine sex-specific trajectories of bone shape change over time. In the proposed study, we will take the advantage of knee radiographs and magnetic resonance images collected annually for 5 years in the Osteoarthritis Initiative.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Specialized Center (P50)
Project #
5P50AR063043-04
Application #
8915952
Study Section
Special Emphasis Panel (ZRG1-EMNR-Q)
Project Start
Project End
2016-08-31
Budget Start
2015-09-01
Budget End
2016-08-31
Support Year
4
Fiscal Year
2015
Total Cost
$90,208
Indirect Cost
Name
University of California Davis
Department
Type
DUNS #
047120084
City
Davis
State
CA
Country
United States
Zip Code
95618
Landsman, Victoria; Fillery, Mark; Vernon, Howard et al. (2018) Sample size calculations for blinding assessment. J Biopharm Stat 28:857-869
Tran, Tuan A; Williams, Lisa M; Bui, Donna et al. (2018) Prospective Pilot Study Comparing Pre- and Postsurgical CTSAQ and Neuro-QoL Questionnaire with Median Nerve High-Resolution Ultrasound Cross-Sectional Areas. J Hand Surg Am 43:184.e1-184.e9
Roghani, Taybeh; Khalkhali Zavieh, Minoo; Rahimi, Abbas et al. (2018) The reliability and validity of a designed setup for the assessment of static back extensor force and endurance in older women with and without hyperkyphosis. Physiother Theory Pract 34:882-893
Wise, Barton L; Niu, Jingbo; Zhang, Yuqing et al. (2018) Bone shape mediates the relationship between sex and incident knee osteoarthritis. BMC Musculoskelet Disord 19:331
Orwoll, Eric S; Wiedrick, Jack; Jacobs, Jon et al. (2018) High-throughput serum proteomics for the identification of protein biomarkers of mortality in older men. Aging Cell 17:
Mohan, Geetha; Lay, Evan Yu-An; Berka, Haley et al. (2017) A Novel Hybrid Compound LLP2A-Ale Both Prevented and Rescued the Osteoporotic Phenotype in a Mouse Model of Glucocorticoid-Induced Osteoporosis. Calcif Tissue Int 100:67-79
Katzman, Wendy B; Parimi, Neeta; Gladin, Amy et al. (2017) Sex differences in response to targeted kyphosis specific exercise and posture training in community-dwelling older adults: a randomized controlled trial. BMC Musculoskelet Disord 18:509
Rogers, Tara S; Blackwell, Terri L; Lane, Nancy E et al. (2017) Rest-activity patterns and falls and fractures in older men. Osteoporos Int 28:1313-1322
Wise, B L; Niu, J; Guermazi, A et al. (2017) Magnetic resonance imaging lesions are more severe and cartilage T2 relaxation time measurements are higher in isolated lateral compartment radiographic knee osteoarthritis than in isolated medial compartment disease - data from the Osteoarthritis Initiat Osteoarthritis Cartilage 25:85-93
Rogers, Tara S; Harrison, Stephanie; Swanson, Christine et al. (2017) Rest-activity circadian rhythms and bone mineral density in elderly men. Bone Rep 7:156-163

Showing the most recent 10 out of 67 publications