Abstract

The aims of the core are to (1) identify and characterize species which are the source of dietary supplements using classical and molecular systematics, (2) determine genetic and cultivation factors that influence the levels of biological compounds thought to be responsible for positive health effects, (3) develop a molecular systematics classification for botanicals, and (4) provide information about botanicals to standardize the phytochemical levels in the plant products. The core uses the resources and facilities of two quality institutions, UCLA and Cal Poly Pomona. UCLA plant molecular biology group will develop the DNA-based taxonomy program and Cal Poly Pomona's School of Agriculture will conduct germplasm and cultivation studies. Cal Poly Pomona will conduct two projects the first will identify the best methods for germination, transplantation, and cultivation of botanicals for commercial use and will examine the best ways for the storage of germplasm (including dormancy requirements) for future cultivation needs. The UCLA facilities will do DNA fingerprinting of botanicals to try to determine the tags or markers associated with specific bioactive components of concern.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Complementary & Alternative Medicine (NCCAM)
Type
Specialized Center (P50)
Project #
3P50AT000151-04S1
Application #
6668218
Study Section
Special Emphasis Panel (ZRG1)
Project Start
2002-08-01
Project End
2003-07-31
Budget Start
Budget End
Support Year
4
Fiscal Year
2002
Total Cost
$159,181
Indirect Cost

  Institution

Name
University of California Los Angeles
Department
Type
DUNS #
119132785
City
Los Angeles
State
CA
Country
United States
Zip Code
90095

  Publications

Aziz, Nabil; Bonavida, Benjamin (2016) Activation of Natural Killer Cells by Probiotics. For Immunopathol Dis Therap 7:41-55
Sadava, David; Still, David W; Mudry, Ryan R et al. (2009) Effect of Ganoderma on drug-sensitive and multidrug-resistant small-cell lung carcinoma cells. Cancer Lett 277:182-9
Lu, Qing-Yi; Zhang, Yanjun; Wang, Yue et al. (2009) California Hass avocado: profiling of carotenoids, tocopherol, fatty acid, and fat content during maturation and from different growing areas. J Agric Food Chem 57:10408-13
Seeram, Navindra P; Zhang, Yanjun; McKeever, Rodney et al. (2008) Pomegranate juice and extracts provide similar levels of plasma and urinary ellagitannin metabolites in human subjects. J Med Food 11:390-4
Mu, L N; Cao, W; Zhang, Z F et al. (2007) Polymorphisms of 5,10-methylenetetralydrofolate reductase (MTHFR), fruit and vegetable intake, and the risk of stomach cancer. Biomarkers 12:61-75
Mu, Li-Na; Cao, Wei; Zhang, Zuo-Feng et al. (2007) Methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms and the risk of primary hepatocellular carcinoma (HCC) in a Chinese population. Cancer Causes Control 18:665-75
Woo, Ho-Hyung; Jeong, Byeong Ryong; Hirsch, Ann M et al. (2007) Characterization of Arabidopsis AtUGT85A and AtGUS gene families and their expression in rapidly dividing tissues. Genomics 90:143-53
Cai, Lin; You, Nai-Chieh Yuko; Lu, Hua et al. (2006) Dietary selenium intake, aldehyde dehydrogenase-2 and X-ray repair cross-complementing 1 genetic polymorphisms, and the risk of esophageal squamous cell carcinoma. Cancer 106:2345-54
Henry, Geneive E; Raithore, Smita; Zhang, Yanjun et al. (2006) Acylphloroglucinol derivatives from Hypericum prolificum. J Nat Prod 69:1645-8
Lu, Hua; Cai, Lin; Mu, Li-Na et al. (2006) Dietary mineral and trace element intake and squamous cell carcinoma of the esophagus in a Chinese population. Nutr Cancer 55:63-70

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