The Johns Hopkins Center for Cancer Complementary Medicine (CAM) will provide internationally recognized state-of-the-art scientific expertise and a powerful interdisciplinary infrastructure. It is our mandate to integrate the science of Complementary and Alternative Medicine (CAM) through interface with practitioners of CAM therapies and through researchers across the broad arenas represented in the three major health Schools of The Johns Hopkins Medical Institutions. Our research program focuses on gender specific cancers, initially breast and prostate cancers. Both the prevalence of these diseases in the UNITED States as well as the prevalence of CAM use by these patients demonstrates that allopathic care is not sufficient either for prevention or treatment of these diseases and that promising CAM modalities must be studied. We are focusing on four aspects of cancer research eminently applicable to CAM, 1) immune surveillance, 2) will be applicable to the general cancer process. Our Center encourages basic studies that are generalizable to the study of cancer mechanism. Our initial studies will aim to establish a series of outcome measures within a system of laboratory cores which will be used in future projects to test for the safety and efficacy of interventions. The elucidation of the mechanism of action can provide a point of departure for future rigorous scientific studies. The initial projects include studies of: 1) the mechanistic assessment of the effects of neuroendocrine stress and Chinese herbs on oxidative genome damage, 2) the development of a model to study the attenuation of cancer pain in a rat model through the use of herbal remedies, 3) Chinese herbal interventions in men with prostate cancer, and 4) a prayer-based intervention in Black women with breast cancer examining the potentially salutary impact of an intervention to ameliorate emotional stress associated with diagnosis and treatment and attendant neuroendocrine and immune responses. The cores include Statistics and Methodology, Laboratory, and Administrative. We have generated a strong institutionally supported formal CAM career training through our Graduate Training Program in Clinical Investigation and mentorship in established laboratories, and a well-defined process for encouraging and enabling developmental projects in CAM. Our mission is strengthened by international links with our Johns Hopkins Singapore campus and access serve as teachers and mentors. The overall goals of the center is to apply state-of-the-art research methodology to highly promising CAM modalities for cancer and to invigorate the intellectual atmosphere with CAM research. This will lead to a new age of integrative, comprehensive care.

National Institute of Health (NIH)
National Center for Complementary & Alternative Medicine (NCCAM)
Specialized Center (P50)
Project #
Application #
Study Section
Special Emphasis Panel (ZAT1)
Program Officer
Sorkin, Barbara C
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Johns Hopkins University
Internal Medicine/Medicine
Schools of Medicine
United States
Zip Code
Slama, Laurence; Jacobson, Lisa P; Li, Xiuhong et al. (2016) Longitudinal Changes Over 10 Years in Free Testosterone Among HIV-Infected and HIV-Uninfected Men. J Acquir Immune Defic Syndr 71:57-64
Lechtzin, Noah; Busse, Anne M; Smith, Michael T et al. (2010) A randomized trial of nature scenery and sounds versus urban scenery and sounds to reduce pain in adults undergoing bone marrow aspirate and biopsy. J Altern Complement Med 16:965-72
Borzan, Jasenka; Tall, Jill M; Zhao, Chengshui et al. (2010) Effects of soy diet on inflammation-induced primary and secondary hyperalgesia in rat. Eur J Pain 14:792-8
Lee, Lawrence S; Wise, Stephen D; Chan, Clark et al. (2008) Possible differential induction of phase 2 enzyme and antioxidant pathways by american ginseng, Panax quinquefolius. J Clin Pharmacol 48:599-609
Mullin, Gerard E; Dobs, Adrian (2007) Vitamin d and its role in cancer and immunity: a prescription for sunlight. Nutr Clin Pract 22:305-22
van Erp, Nielka P; Gelderblom, Hans; Karlsson, Mats O et al. (2007) Influence of CYP3A4 inhibition on the steady-state pharmacokinetics of imatinib. Clin Cancer Res 13:7394-400
Li, Jing; Zhao, Ming; He, Ping et al. (2007) Differential metabolism of gefitinib and erlotinib by human cytochrome P450 enzymes. Clin Cancer Res 13:3731-7
van Erp, Nielka P H; Baker, Sharyn D; Zhao, Ming et al. (2005) Effect of milk thistle (Silybum marianum) on the pharmacokinetics of irinotecan. Clin Cancer Res 11:7800-6
Tall, Jill M; Seeram, Navindra P; Zhao, Chengshui et al. (2004) Tart cherry anthocyanins suppress inflammation-induced pain behavior in rat. Behav Brain Res 153:181-8
Zhao, Chengshui; Wacnik, Paul W; Tall, Jill M et al. (2004) Analgesic effects of a soy-containing diet in three murine bone cancer pain models. J Pain 5:104-10

Showing the most recent 10 out of 14 publications