At mepopause most women lose their gepder-related biological protection and develop symptoms that adversely affect their lives, e.g., hypertension, stroke and insulin resistance. The loss of estrogen appears to be central to the deleterious effects, but recent findings strongly discourage the use of hormone replacement therapy. A growing number of women have turned to dietary supplements to alleviate these effects, but their efficacy and safety are largely untested. In female ovariectomized spontaneously hypertensive stroke prone rats, three botanical extracts (e.g., genistein, kudzu and grape seed extract) can jpdependently blunt hypertension and decrease cognitive decline. In this model resistance vessels are compromised by the loss of estrogen, and these effects are significantly blunted by dietary polyphenols.? Determining the mechanism of action of these botanicals has been difficult, because the polyphenols are typically metabolized rapidly, and therefore, their distribution into body compartments is not easily followed.? However, our preliminary data suggest that the primary polyphenol in kudzu root, i.e., puerarin, is transported to body compartmepts ip a rapid and unmetabolized state, and thus, its distribution can be readily traced. This suggests that kudzu polyphenols may provide a useful tool to uncover mechanisms by which polyphenols protect against diseases. These studies will elucidate the mechanism(s) by which kudzu root blunts the cascades leading to hypertension, endothelial dysfunction and cognitive loss in this model and compare these mechanisms to those underlying similar effects of the major soy polyphenol, i.e., genistein. These studies will elucidate the bioavailability, safety, efficacy, mechanisms and protein interactions that underlie the beneficial actions. Previous studies used a narrow approach that examined only one or two dimensions of the effects of botanicals, but we propose a multidisciplinary approach, which will elucidate a broad range of the health benefits/risks of botanical treatments.

Agency
National Institute of Health (NIH)
Institute
National Center for Complementary & Alternative Medicine (NCCAM)
Type
Specialized Center (P50)
Project #
5P50AT000477-09
Application #
7625957
Study Section
Special Emphasis Panel (ZAT1)
Project Start
Project End
Budget Start
2008-04-01
Budget End
2009-03-31
Support Year
9
Fiscal Year
2008
Total Cost
$152,721
Indirect Cost
Name
Purdue University
Department
Type
DUNS #
072051394
City
West Lafayette
State
IN
Country
United States
Zip Code
47907
Barnes, Stephen; Quinlan, Roy A (2017) Small molecules, both dietary and endogenous, influence the onset of lens cataracts. Exp Eye Res 156:87-94
Jacobi, Jennifer L; Yang, Bo; Li, Xu et al. (2016) Impacts on Sirtuin Function and Bioavailability of the Dietary Bioactive Compound Dihydrocoumarin. PLoS One 11:e0149207
Jackson, George S; Muzikar, Paul; Goehring, Brent (2015) A Bayesian approach to an interlaboratory comparison. Chemometr Intell Lab Syst 141:94-99
Pawlowski, Jessica W; Martin, Berdine R; McCabe, George P et al. (2015) Impact of equol-producing capacity and soy-isoflavone profiles of supplements on bone calcium retention in postmenopausal women: a randomized crossover trial. Am J Clin Nutr 102:695-703
Roysommuti, Sanya; Kritsongsakchai, Angkana; Wyss, J Michael (2015) The Effect of Perinatal Taurine on Adult Renal Function Does Not Appear to Be Mediated by Taurine's Inhibition of the Renin-Angiotensin System. Adv Exp Med Biol 803:665-77
Legette, LeeCole L; Prasain, Jeevan; King, Jennifer et al. (2014) Pharmacokinetics of equol, a soy isoflavone metabolite, changes with the form of equol (dietary versus intestinal production) in ovariectomized rats. J Agric Food Chem 62:1294-300
Theis, Whitney S; Andringa, Kelly K; Millender-Swain, Telisha et al. (2014) Ozone inhalation modifies the rat liver proteome. Redox Biol 2:52-60
Roysommuti, Sanya; Wyss, J Michael (2014) Perinatal taurine exposure affects adult arterial pressure control. Amino Acids 46:57-72
Nakatsu, Cindy H; Armstrong, Arthur; Clavijo, Andrea P et al. (2014) Fecal bacterial community changes associated with isoflavone metabolites in postmenopausal women after soy bar consumption. PLoS One 9:e108924
Abdul Roda, Mojtaba; Sadik, Mariam; Gaggar, Amit et al. (2014) Targeting prolyl endopeptidase with valproic acid as a potential modulator of neutrophilic inflammation. PLoS One 9:e97594

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