This application is for a renewal of our Botanical Dietary Supplement Research Center. Our Botanical Research Center is a collaborative effort between the Pennington Biomedical Research Center of the Louisiana State University (LSU) System and the Department of Plant Biology and Pathology of Rutgers University. The theme of the Center is Botanicals and Metabolic Resiliency. Specifically, our Center is poised to take the next logical scientific step in evaluating the role of botanicals for promoting human health by specifically focusing on the functional aspects and mechanisms by which botanicals promote metabolic resilience and general health. As such, our botanical research center will pursue exciting, novel, and in-depth hypotheses with specific emphasis on cellular mechanisms of action by which botanicals preserve and maintain normal tissue function and resist tissue dysfunction when exposed to significant environmental stressors, such as occur as part of an obesogenic environment. The resiliency promoted by botanicals will maintain whole body health. We refer to this characteristic as botano-metabolic resiliency. Our Botanical Research Center will consist of three (3) highly collaborative research projects, an Integrative Biology Core, a Botanical core, and an Administrative core. Our Center has three aims which will promote a collaborative and interactive research environment, will identify and evaluate botanicals with potential efficacy in promoting metabolic resiliency, and will expand the critical mass of investigators addressing botanical research. For this grant cycle, we are proposing to expand studies on botanicals for which we have significant data (Artemisia sp, Projects 1 and 2), while also evaluating promising new leads (i.e., Groundsel bush [Baccharis halimifolia]) identified in our innovative screening program. In addition, we will study botanicals that are of great interest to the US consumer and of public health interest and whose mechanisms of action appear central to our theme (i.e., Trigonella foenum gracecum [fenugreek], Moringa oleifera Lam., and Momordica charantia [bitter melon]) (Projects 1, 2, 3). We have added additional state-of-the-art methodologies (e.g, live cell calcium imaging, gut microbiome assessment) and propose to specifically leverage our expertise in functional genomics/gene expression by exploring the individual variability in responses to botanicals.
Given the complications that are present with development of obesity and type 2 diabetes, it is imperative that we implement effective strategies to maintain normal tissue function in the presence of an obesogenic environment. We propose to evaluate how botanicals enhance an individual's ability to resist disease states.
|Graf, Brittany L; Zhang, Li; Corradini, Maria G et al. (2018) Physicochemical differences between malanga (Xanthosoma sagittifolium) and potato (Solanum tuberosum) tubers are associated with differential effects on the gut microbiome. J Funct Foods 45:268-276|
|Kim, Youjin; Jaja-Chimedza, Asha; Merrill, Daniel et al. (2018) A 14-day repeated-dose oral toxicological evaluation of an isothiocyanate-enriched hydro-alcoholic extract from Moringa oleifera Lam. seeds in rats. Toxicol Rep 5:418-426|
|Rebello, Candida J; Nikonova, Elena V; Zhou, Sharon et al. (2018) Effect of Lorcaserin Alone and in Combination with Phentermine on Food Cravings After 12-Week Treatment: A Randomized Substudy. Obesity (Silver Spring) 26:332-339|
|Forney, Laura A; Lenard, Natalie R; Stewart, Laura K et al. (2018) Dietary Quercetin Attenuates Adipose Tissue Expansion and Inflammation and Alters Adipocyte Morphology in a Tissue-Specific Manner. Int J Mol Sci 19:|
|Losso, Jack N; Finley, John W; Karki, Namrata et al. (2018) Pilot Study of the Tart Cherry Juice for the Treatment of Insomnia and Investigation of Mechanisms. Am J Ther 25:e194-e201|
|Yu, Yongmei; Mendoza, Tamra M; Ribnicky, David M et al. (2018) An Extract of Russian Tarragon Prevents Obesity-Related Ectopic Lipid Accumulation. Mol Nutr Food Res 62:e1700856|
|Zhang, Li; Carmody, Rachel N; Kalariya, Hetal M et al. (2018) Grape proanthocyanidin-induced intestinal bloom of Akkermansia muciniphila is dependent on its baseline abundance and precedes activation of host genes related to metabolic health. J Nutr Biochem 56:142-151|
|Boudreau, Anik; Fuller, Scott; Ribnicky, David M et al. (2018) Groundsel Bush (Baccharis halimifolia) Extract Promotes Adipocyte Differentiation In Vitro and Increases Adiponectin Expression in Mature Adipocytes. Biology (Basel) 7:|
|Bruce-Keller, Annadora J; Salbaum, J Michael; Berthoud, Hans-Rudolf (2018) Harnessing Gut Microbes for Mental Health: Getting From Here to There. Biol Psychiatry 83:214-223|
|Knott, Eric J; Richard, Allison J; Mynatt, Randall L et al. (2017) Fenugreek supplementation during high-fat feeding improves specific markers of metabolic health. Sci Rep 7:12770|
Showing the most recent 10 out of 174 publications