Abstract

This core continues the activities of the administrative and data analysis core from the Iowa BotanicalCenter. Support for bioinformatics was added with the growing importance of analysis of complex datamatrices.Four objectives are proposed:1) Provide coordination and integrate communication among projects and cores and with the externaladvisors to facilitate the transfer of both raw materials and information and coordinate planning and reportingfor all investigations. This includes coordination of the Internal Steering Committee (ISC) and the ExternalAdvisory Committee (EAC); and overseeing core utilization and prioritization.2) Oversee experimental design, data management and statistical analysis for all Center research.3) Develop bioinformatics functions to analyze complex biological relationships and incorporate thesefunctions into existing bioinformatics tools,4) Support and administer pilot research projects.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Complementary & Alternative Medicine (NCCAM)
Type
Specialized Center (P50)
Project #
9P50AT004155-06
Application #
7293908
Study Section
Special Emphasis Panel (ZAT1-SM (05))
Project Start
2007-04-01
Project End
2010-03-31
Budget Start
2007-06-01
Budget End
2008-05-31
Support Year
6
Fiscal Year
2007
Total Cost
$279,704
Indirect Cost

  Institution

Name
Iowa State University
Department
Type
DUNS #
005309844
City
Ames
State
IA
Country
United States
Zip Code
50011

  Publications

Haarberg, Kelley Mk; Wymore Brand, Meghan J; Overstreet, Anne-Marie C et al. (2015) Orally administered extract from Prunella vulgaris attenuates spontaneous colitis in mdr1a(-/-) mice. World J Gastrointest Pharmacol Ther 6:223-37
Hammer, Kimberly D P; Birt, Diane F (2014) Evidence for contributions of interactions of constituents to the anti-inflammatory activity of Hypericum perforatum. Crit Rev Food Sci Nutr 54:781-9
Kraus, George A; Chaudhary, Divya; Riley, Sean et al. (2013) Synthesis of 3-farnesyl salicylic acid, a novel antimicrobial from Piper multiplinervium. Nat Prod Commun 8:911-3
Qiang, Zhiyi; Hauck, Cathy; McCoy, Joe-Ann et al. (2013) Echinacea sanguinea and Echinacea pallida extracts stimulate glucuronidation and basolateral transfer of Bauer alkamides 8 and 10 and ketone 24 and inhibit P-glycoprotein transporter in Caco-2 cells. Planta Med 79:266-74
Huang, Nan; Singh, Navrozedeep; Yoon, Kyoungjin et al. (2013) The immuno-regulatory impact of orally-administered Hypericum perforatum extract on Balb/C mice inoculated with H1n1 influenza A virus. PLoS One 8:e76491
Feng, Yaping; Hurst, Jonathan; Almeida-De-Macedo, Marcia et al. (2012) Massive human co-expression network and its medical applications. Chem Biodivers 9:868-87
Qu, Luping; Widrlechner, Mark P (2012) Reduction of Seed Dormancy in Echinacea pallida (Nutt.) Nutt. by In-dark Seed Selection and Breeding. Ind Crops Prod 36:88-93
Wurtele, Eve Syrkin; Chappell, Joe; Jones, A Daniel et al. (2012) Medicinal plants: a public resource for metabolomics and hypothesis development. Metabolites 2:1031-59
Zhang, Xiaozhu; Rizshsky, Ludmila; Hauck, Catherine et al. (2012) Bauer ketones 23 and 24 from Echinacea paradoxa var. paradoxa inhibit lipopolysaccharide-induced nitric oxide, prostaglandin E2 and cytokines in RAW264.7 mouse macrophages. Phytochemistry 74:146-58
Huang, Nan; Rizshsky, Ludmila; Hauck, Catherine C et al. (2012) The inhibition of lipopolysaccharide-induced macrophage inflammation by 4 compounds in Hypericum perforatum extract is partially dependent on the activation of SOCS3. Phytochemistry 76:106-16

Showing the most recent 10 out of 43 publications