In order to have a complete understanding of the botanical reference material selected for study under this Botanical Research Center (BRC), Licorice - Glycyrrhiza glabra Linne var glabra. Wild Yam - Dioscorea villosa L., and Dong Quai - Angelica sinensis (Oliv.) Diels, one needs to fully evaluate not only the morphological makeup of the material but also examine the requisite phytochemical proflle and conduct the subsequent analytical assessment ofthe relevant """"""""bio-markers"""""""" for each selected species. To accomplish this task, the Botanical Identiflcation, Characterization Quality Assurance and Quality Control Core (Core A) will meet the following speciflc aims. Speciflc Aim 1. Authenticate botanical samples and extracts ofthe aforementioned species through the utilization of appropriate microscopic techniques and/or phytochemical evaluation (HPTLC, HPLC, etc.).
Specific Aim 2. Provide authenticated plant specimens, bulk extracts, semi-purified fracfions, and pure compounds of the listed plants and closely related species for biological assessment within the other projects. Isolated pure compounds will be utilized for refinement of analytical methodologies and related speciation analysis.
Specific Aim 3. Provide scale up extracfion and isolation capabilifies as needed for the requisite projects. Each of the outiined aims will be tailored to suit the particular research requirements for the associated Research Projects 1, 2 and 3.

Public Health Relevance

The purpose of this core will be to facilitate the assimilafion of relevant phytochemical data and morphological idenfificafion characterisfics for the selected plants and dietary supplements as outlined within the overall proposed Botanical Research Center enfitiled Botanical Estrogens: Mechanisms, Dose, and Target Tissues

Agency
National Institute of Health (NIH)
Institute
National Center for Complementary & Alternative Medicine (NCCAM)
Type
Specialized Center (P50)
Project #
1P50AT006268-01
Application #
8007128
Study Section
Special Emphasis Panel (ZAT1-SM (19))
Project Start
2010-07-01
Project End
2011-06-30
Budget Start
2010-07-01
Budget End
2011-08-31
Support Year
1
Fiscal Year
2010
Total Cost
$147,034
Indirect Cost
Name
University of Illinois Urbana-Champaign
Department
Type
DUNS #
041544081
City
Champaign
State
IL
Country
United States
Zip Code
61820
Kundu, Payel; Neese, Steven L; Bandara, Suren et al. (2018) The effects of the botanical estrogen, isoliquiritigenin on delayed spatial alternation. Neurotoxicol Teratol 66:55-62
Kundu, Payel; Korol, Donna L; Bandara, Suren et al. (2018) Licorice root components mimic estrogens in an object location task but not an object recognition task. Horm Behav 103:97-106
Dash, Michael B; Ajayi, Stephen; Folsom, Lynde et al. (2018) Spontaneous Infraslow Fluctuations Modulate Hippocampal EPSP-PS Coupling. eNeuro 5:
Korol, Donna L; Wang, Wei (2018) Using a memory systems lens to view the effects of estrogens on cognition: Implications for human health. Physiol Behav 187:67-78
Lu, Wenwen; Katzenellenbogen, Benita S (2017) Estrogen Receptor-? Modulation of the ER?-p53 Loop Regulating Gene Expression, Proliferation, and Apoptosis in Breast Cancer. Horm Cancer 8:230-242
Menazza, Sara; Sun, Junhui; Appachi, Swathi et al. (2017) Non-nuclear estrogen receptor alpha activation in endothelium reduces cardiac ischemia-reperfusion injury in mice. J Mol Cell Cardiol 107:41-51
Wang, Wendan; Belosay, Aashvini; Yang, Xujuan et al. (2016) Effects of letrozole on breast cancer micro-metastatic tumor growth in bone and lung in mice inoculated with murine 4T1 cells. Clin Exp Metastasis 33:475-85
Chambliss, Ken L; Barrera, Jose; Umetani, Michihisa et al. (2016) Nonnuclear Estrogen Receptor Activation Improves Hepatic Steatosis in Female Mice. Endocrinology 157:3731-3741
Boonmuen, Nittaya; Gong, Ping; Ali, Zulfiqar et al. (2016) Licorice root components in dietary supplements are selective estrogen receptor modulators with a spectrum of estrogenic and anti-estrogenic activities. Steroids 105:42-9
Weis, Karen E; Raetzman, Lori T (2016) Isoliquiritigenin exhibits anti-proliferative properties in the pituitary independent of estrogen receptor function. Toxicol Appl Pharmacol 313:204-214

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