Abstract

This application for continuation of the Specialized Program of Research Excellence (SPORE) in Gastro-intestinal Cancer at The Johns Hopkins Medical Institutions supports a highly interactive, multidisciplinary program of translational research directed at reducing incidence of and mortality from colorectal and pancreatic cancer. The SPORE consists of 4 research programs with 8 projects built upon successful existing programs: Program 1 - Translational applications of molecular genetics for the early detection of colorectal and pancreatic cancer. Project 1A - Mutant genes in feces for early detection of colorectal neoplasms (Bernard Levin, M.D. Project 1B - New genetic markers for pancreatic cancer (Scott Kern, M.D.). Project 1C - Targets for screening in pancreatic neoplasia (Scott Kern, M.D.). Program 2 - New prognostic and diagnostic markers for colorectal and pancreatic cancer. Project 2 - Molecular markers for metastasis of colorectal cancer (Stanley Hamilton, M.D.). Program 3 - Prevention of colorectal and pancreatic cancer in genetically-destined patients by molecular genetic approaches. Project 3A - Genetic analysis of hereditary colorectal cancer syndromes (Kenneth Kinzler, Ph.D.). Project 3B - Agents and mechanisms of tumor prevention in the MIN model of familial adenomatous polyposis (Stanley Hamilton,M.D.). Project 3C - Markers for risk in familial pancreatic cancer (Ralph Hruban, M.D.). Program 4 - Novel therapies for pancreatic and colorectal cancer. Project 4 -Identification of T cell recognition targets in pancreatic adenocarcinomas (Elizabeth Jaffee, M.D.). Four cores support the research programs: Core l - SPORE administration and communication (Stanley Hamilton, M.D.). Core 2 - Human tissue resource and logistics (Stanley Hamilton, M.D.). Core 3 - Colorectal and pancreatic cancer patient registry (Francis Giardiello, M.D., and Ralph Hruban, M.D.). Core 4 - Biostatistics (Steven Goodman, M.D., Ph.D.). The SPORE includes a major Developmental Research Program (Bert Vogelstein, M.D.) for rapid funding of innovative projects and a Career Development Program (Stanley Hamilton, M.D.).

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center (P50)
Project #
5P50CA062924-06
Application #
2856361
Study Section
Special Emphasis Panel (SRC (21))
Program Officer
Agarwal, Rajeev K
Project Start
1993-09-30
Project End
2001-12-31
Budget Start
1999-01-01
Budget End
1999-12-31
Support Year
6
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
Johns Hopkins University
Department
Pathology
Type
Schools of Medicine
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218

  Publications

Deng, Yang; Tu, Huakang; Pierzynski, Jeanne A et al. (2018) Determinants and prognostic value of quality of life in patients with pancreatic ductal adenocarcinoma. Eur J Cancer 92:20-32
Tamura, Koji; Yu, Jun; Hata, Tatsuo et al. (2018) Mutations in the pancreatic secretory enzymes CPA1 and CPB1 are associated with pancreatic cancer. Proc Natl Acad Sci U S A 115:4767-4772
Chung, Liam; Thiele Orberg, Erik; Geis, Abby L et al. (2018) Bacteroides fragilis Toxin Coordinates a Pro-carcinogenic Inflammatory Cascade via Targeting of Colonic Epithelial Cells. Cell Host Microbe 23:203-214.e5
Nakamura, Hideki; Lee, Albert A; Afshar, Ali Sobhi et al. (2018) Intracellular production of hydrogels and synthetic RNA granules by multivalent molecular interactions. Nat Mater 17:79-89
Al Efishat, Mohammad A; Attiyeh, Marc A; Eaton, Anne A et al. (2018) Multi-institutional Validation Study of Pancreatic Cyst Fluid Protein Analysis for Prediction of High-risk Intraductal Papillary Mucinous Neoplasms of the Pancreas. Ann Surg 268:340-347
Cruz-Correa, Marcia; Hylind, Linda M; Marrero, Jessica Hernandez et al. (2018) Efficacy and Safety of Curcumin in Treatment of Intestinal Adenomas in Patients With Familial Adenomatous Polyposis. Gastroenterology 155:668-673
Christmas, Brian J; Rafie, Christine I; Hopkins, Alexander C et al. (2018) Entinostat Converts Immune-Resistant Breast and Pancreatic Cancers into Checkpoint-Responsive Tumors by Reprogramming Tumor-Infiltrating MDSCs. Cancer Immunol Res 6:1561-1577
Blair, Alex B; Murphy, Adrian (2018) Immunotherapy as a treatment for biliary tract cancers: A review of approaches with an eye to the future. Curr Probl Cancer 42:49-58
Raman, Aadhithya; Lennon, Anne Marie (2018) Cyst Fluid Biomarkers - Diagnosis and Prediction of Malignancy for Cystic Lesions of the Pancreas. Visc Med 34:178-181
Noë, Michaël; Pea, Antonio; Luchini, Claudio et al. (2018) Whole-exome sequencing of duodenal neuroendocrine tumors in patients with neurofibromatosis type 1. Mod Pathol 31:1532-1538

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