This application for continuation of the Specialized Program of Research Excellence (SPORE) in Gastrointestinal Cancer at the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins supports a highly interactive, multidisciplinary program. Four research projects, four cores, a career development and a research developmental program are proposed to extend our translational research in colorectal and pancreatic cancer. Project 1, Improving Pancreatic Cancer Risk Assessment: Clinical/Population Leader Dr. Alison Klein and Basic Science Leader Dr. Michael Goggins. Project 2, Neo-antigen Vaccines for Pancreatic Cancer and Colorectal Cancer. Basic Science Leaders Drs. Elizabeth Jaffee and Drew Pardoll and Clinical Leaders Drs. Daniel Laheru and Nilo Azad. Project 3, Diagnosis and Management of Pancreatic Cysts: Clinical Leader Dr. Anne Marie Lennon and Basic Science Leaders Drs. Ken Kinzler and Bert Vogelstein Project 4, Using TME genetics and immunobiology to drive combination immunotherapies. Basic Science Leader Dr. Elizabeth Jaffee and Clinical Leaders: Drs. Dung Le and Lei Zheng The cores support the research programs (Admin Core: Administration and Communication, Dr. Alison Klein; Core 1, Statistics/Bioinformatics, Drs. Elizabeth Sugar and Robert Scharpf: Core 2, Human Tissue Research and Logistics, Dr. Robert Anders; Core 3, Familial and Population Cancer Registries, Drs. Frank Giardiello and Alison Klein. The Career Development Program (Dr. Scott Kern) aids the emergence of new investigators and the Research Developmental Program (Dr. Bert Vogelstein) provides rapid funding of innovative directions

Public Health Relevance

Our SPORE provides a wide spectrum of capabilities enabling a broad translational research program aimed at reducing the disease burden of gastrointestinal cancers though improved risk assessment, early detection and therapeutic interventions.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center (P50)
Project #
5P50CA062924-26
Application #
10005974
Study Section
Special Emphasis Panel (ZCA1)
Program Officer
Nothwehr, Steven F
Project Start
1997-02-28
Project End
2023-08-31
Budget Start
2020-09-01
Budget End
2021-08-31
Support Year
26
Fiscal Year
2020
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21205
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