The goal of the Biostatistics Core is to collaborate with SPORE investigators and other core resourcescientists to enhance the quality of the research undertaken in the University of Michigan Prostate SPORE.The Core personnel have been chosen because of their expertise in relevant areas of Biostatistics andbecause of their experience and knowledge of prostate cancer.Biostatistics Core personnel will collaborate with every one of the four proposed projects. The Core will alsonteract with the other cores and also with all funded development awards, and, thus, this core is cruciallymportant to the SPORE. Personnel from the core will interact with the investigators in all stages of theresearch, beginning with the formulation of the research question, through the experimental design stageand data collection stage, to data analysis and interpretation, to the writing of reports and dissemination ofresults. Two areas where biostatistical expertise is indispensable are in experimental design and dataanalysis. It will be apparent from this proposal that Core personnel have played a significant role indesigning the proposed experiments and in planning the data analysis.
The Specific Aims of the Core are 1)assist investigators in the design of clinical and laboratory experiments; 2) assist investigators in the analysisand interpretation of data from clinical and laboratory experiments and in writing of scientific manuscriptsrelaying prostate cancer SPORE results to the scientific community; and 3) undertake translationalbiostatistics research to develop methodology relevant to prostate cancer.
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