The overall goal of the University of Texas M. D. Anderson Cancer Center (MDACC) SPORE is to reduce the morbidity and mortality of ovarian cancer through innovative translational research in the detection and treatment of ovarian cancer based upon the genomics and biology of the disease. Our Cancer Center contains a unique concentration of talented investigators who are dedicated to translational, clinical, fundamental and population-based ovarian cancer research. To complete the aims of the SPORE, we have assembled an exceptional group of collaborating investigators from 17 other universities and major hospitals. MDACC cares for a large number of patients. In 2004, research-driven multidisciplinary care was provided to 469 new patients with ovarian and primary peritoneal carcinoma. Our institution has given high priority to ovarian cancer research through recruitment, salary support, clinical facilities, laboratory space and philanthropic funds. Over the last five years, MDACC with the help of the SPORE has recruited 10 outstanding young faculty members, strengthened the research infrastructure, funded 17 developmental research projects and supported 10 career development awardees. Of the 10 who received SPORE career development support, 7 have achieved peer reviewed funding and two are now Co-PIs on SPORE projects. Over the last 5 years SPORE investigators have had 231 articles, reviews, editorials and chapters regarding ovarian cancer published or in press. SPORE investigators have: identified novel candidate markers for early detection of ovarian cancer using proteomic, genomic and lipomic techniques; defined factors regulating ovarian angiogenesis; demonstrated potentiation of chemotherapy by adenovirus E1A in the absence of HER-2 overexpression; evaluated novel inhibitors of the PIS kinase pathway; and defined genomic markers for poor prognosis that contain therapeutic targets. With the help of the SPORE, investigators have competed successfully for 23 peer-reviewed grants in ovarian cancer biology. Renewal of this SPORE will preserve and enhance our ability to translate insights from cancer biology to more effective detection and treatment of patients with ovarian cancer. The SPORE includes five projects that deal with 1) early detection of ovarian cancer; 2) anti-vascular therapy; 3) gene therapy with E1A and paclitaxel; 4) the PI3 kinase pathway as a target for therapy; and 5) genomic targets for prognosis and therapy. Three Cores (Administrative, Biostatistics and Pathology) will continue to facilitate completion of the proposed projects. Developmental research and career development programs have been strengthened and extended to other institutions. Perspective will continue to be provided by internal, external and advocate advisors.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center (P50)
Project #
5P50CA083639-09
Application #
7499746
Study Section
Special Emphasis Panel (ZCA1-GRB-I (O1))
Program Officer
Arnold, Julia T
Project Start
1999-09-30
Project End
2010-08-31
Budget Start
2008-09-04
Budget End
2009-08-31
Support Year
9
Fiscal Year
2008
Total Cost
$2,180,816
Indirect Cost
Name
University of Texas MD Anderson Cancer Center
Department
Miscellaneous
Type
Other Domestic Higher Education
DUNS #
800772139
City
Houston
State
TX
Country
United States
Zip Code
77030
Rhyasen, Garrett W; Yao, Yi; Zhang, Jingwen et al. (2018) BRD4 amplification facilitates an oncogenic gene expression program in high-grade serous ovarian cancer and confers sensitivity to BET inhibitors. PLoS One 13:e0200826
Chen, Jian; Zaidi, Sobia; Rao, Shuyun et al. (2018) Analysis of Genomes and Transcriptomes of Hepatocellular Carcinomas Identifies Mutations and Gene Expression Changes in the Transforming Growth Factor-? Pathway. Gastroenterology 154:195-210
Sun, Chaoyang; Yin, Jun; Fang, Yong et al. (2018) BRD4 Inhibition Is Synthetic Lethal with PARP Inhibitors through the Induction of Homologous Recombination Deficiency. Cancer Cell 33:401-416.e8
Hu, Xiaowen; Sood, Anil K; Dang, Chi V et al. (2018) The role of long noncoding RNAs in cancer: the dark matter matters. Curr Opin Genet Dev 48:8-15
Jung, Youn-Sang; Wang, Wenqi; Jun, Sohee et al. (2018) Deregulation of CRAD-controlled cytoskeleton initiates mucinous colorectal cancer via ?-catenin. Nat Cell Biol 20:1303-1314
Jung, Youn-Sang; Jun, Sohee; Kim, Moon Jong et al. (2018) TMEM9 promotes intestinal tumorigenesis through vacuolar-ATPase-activated Wnt/?-catenin signalling. Nat Cell Biol 20:1421-1433
Nagaraja, Archana S; Dood, Robert L; Armaiz-Pena, Guillermo et al. (2018) Adrenergic-mediated increases in INHBA drive CAF phenotype and collagens. JCI Insight 3:
Seo, Hyeonglim; Choi, Ikjang; Whiting, Nicholas et al. (2018) Hyperpolarized Porous Silicon Nanoparticles: Potential Theragnostic Material for 29 Si Magnetic Resonance Imaging. Chemphyschem 19:2143-2147
Mitamura, T; Pradeep, S; McGuire, M et al. (2018) Induction of anti-VEGF therapy resistance by upregulated expression of microseminoprotein (MSMP). Oncogene 37:722-731
Yuan, Jiao; Hu, Zhongyi; Mahal, Brandon A et al. (2018) Integrated Analysis of Genetic Ancestry and Genomic Alterations across Cancers. Cancer Cell 34:549-560.e9

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