This study extends an initial assessment of 765 adolescent offspring (G3s) of the G2 parents enrolled in the New England Family Study (NEFS). The study will capitalize on the unique and extensive individual and family data being collected from both parents and offspring as part of the TTURC-1. The study proposes to conduct follow-up assessments on two occasions to continue to collect individual level data and expands the transdisciplinary (TD) focus of the NEFS study to include information on social contexts. This will provide information at three time points to examine prospectively the mediators and moderators of the effects of neighborhood factors (e.g. SES) on smoking progression and on combined alcohol and other drug use (ATOD). Primary aims include: a). to examine indices of neighborhood disadvantage on smoking progression and ATOD; b). to investigate tobacco access as a mediator of the relationship between neighborhood factor and smoking progression and ATOD; c). to investigate family factors as moderators of the relationship between neighborhood attributes and smoking progression and ATOD. Several exploratory, analyses will also be conducted to examine, for example, individual differences in susceptibility, (e.g., psychopathology) as moderators. This study brings a TD perspective to increase the understanding of the mechanisms underlying the relationships among previously disparate domains of neighborhood, social context, family, and individual differences and the progression of smoking and ATOD. This provides a unique opportunity to expand the experiences of scientists from different backgounds in a TD team effort to better understand interrelationships among contextual, family and individual level. This builds on exciting recent work that suggests that some of the key determinants of smoking progression include community contexts.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Specialized Center (P50)
Project #
Application #
Study Section
Special Emphasis Panel (ZCA1)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Butler Hospital (Providence, RI)
United States
Zip Code
Allwood, Maureen A; Gaffey, Allison E; Vergara-Lopez, Chrystal et al. (2017) Stress through the mind of the beholder: preliminary differences in child and maternal perceptions of child stress in relation to child cortisol and cardiovascular activity. Stress 20:341-349
Paradis, Angela D; Shenassa, Edmond D; Papandonatos, George D et al. (2017) Maternal smoking during pregnancy and offspring antisocial behaviour: findings from a longitudinal investigation of discordant siblings. J Epidemiol Community Health 71:889-896
Non, Amy L; Román, Jorge Carlos; Gross, Christopher L et al. (2016) Early childhood social disadvantage is associated with poor health behaviours in adulthood. Ann Hum Biol 43:144-53
Paradis, Angela D; Koenen, Karestan C; Fitzmaurice, Garrett M et al. (2016) Impact of persistent and adolescent-limited antisocial behaviour on adult health outcomes. J Epidemiol Community Health 70:1004-10
de Dios, Marcel A; Stanton, Cassandra A; Cano, Miguel Ángel et al. (2016) The Influence of Social Support on Smoking Cessation Treatment Adherence Among HIV+ Smokers. Nicotine Tob Res 18:1126-33
Paradis, Angela D; Fitzmaurice, Garrett M; Koenen, Karestan C et al. (2015) A prospective investigation of neurodevelopmental risk factors for adult antisocial behavior combining official arrest records and self-reports. J Psychiatr Res 68:363-70
Laurent, Heidemarie K; Stroud, Laura R; Brush, Bridget et al. (2015) Secretory IgA reactivity to social threat in youth: Relations with HPA, ANS, and behavior. Psychoneuroendocrinology 59:81-90
Stinson, Lynda J; Stroud, Laura R; Buka, Stephen L et al. (2015) Prospective evaluation of associations between prenatal cortisol and adulthood coronary heart disease risk: the New England family study. Psychosom Med 77:237-45
Shenassa, Edmond D; Papandonatos, George D; Rogers, Michelle L et al. (2015) Elevated risk of nicotine dependence among sib-pairs discordant for maternal smoking during pregnancy: evidence from a 40-year longitudinal study. Epidemiology 26:441-7
Mays, Darren; Gilman, Stephen E; Rende, Richard et al. (2014) Parental smoking exposure and adolescent smoking trajectories. Pediatrics 133:983-91

Showing the most recent 10 out of 108 publications