This project will involve participation of 200 men aged 50 and older who have been diagnosed and treated (radical prostatectomy, beam radiation) for localized prostate cancer. The study will use a 2x4 randomized experimental design with experimental condition (10-wk Cognitive- Behavioral Stress Management, CBSM; 1-day CBSM seminar) as the between-group factor and time point (pre-psychosocial intervention, post- psychosocial intervention, 6-month and 12-month follow-up) as the within-group factor. We intend to test the effects of the 10-wk CBSM program on quality of life (QOL), indicators (general QOL; prostate cancer specific QOL; positive growth negative affect, fatigue, sexuality) and immune system status (natural killer [NK] cell number, NK cell cytotoxicity) across the study period. We also intend to assess mediators of the 10 wk CBSM program effects on QOL by associating QOL changes with the following intervention process: (a) changes in cognitive appraisals (increased optimism, increased positive reframing); (b) increases in coping self-efficacy; (c) increases in emotional processing (increased emotional awareness and emotional expression); (d) increases in social support provisions; (e) increases in free testosterone and DHEA- S; (f) decreases in physiological arousal as induced by 24-hour output of norepinephrine, epinephrine and cortisol; and (g) decreases in neuropeptide Y. Finally, we intend to determine the mediators of CBSM on immune system status (NK cell number; NK cell cytotoxicity) by associating immune system changes with psychosocial (QOL indicators) and neurohormonal )catecholamines, cortisol, reproductive hormones, neuropeptide Y) intervention induced changes.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center (P50)
Project #
5P50CA084944-02
Application #
6346065
Study Section
Special Emphasis Panel (ZRG1)
Project Start
2000-09-01
Project End
2001-08-31
Budget Start
Budget End
Support Year
2
Fiscal Year
2000
Total Cost
$263,179
Indirect Cost
Name
University of Miami Coral Gables
Department
Type
DUNS #
City
Coral Gables
State
FL
Country
United States
Zip Code
33146
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Zhou, Eric S; Penedo, Frank J; Lewis, John E et al. (2010) Perceived stress mediates the effects of social support on health-related quality of life among men treated for localized prostate cancer. J Psychosom Res 69:587-90
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Marion, Ilona; Antoni, Michael; Pereira, Deidre et al. (2009) Distress, sleep difficulty, and fatigue in women co-infected with HIV and HPV. Behav Sleep Med 7:180-93
Traeger, Lara; Penedo, Frank J; Gonzalez, Jeffrey S et al. (2009) Illness perceptions and emotional well-being in men treated for localized prostate cancer. J Psychosom Res 67:389-97

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