The future development and dissemination of molecular imaging research depends on the availabilityof scientists who are well grounded not only in their basic discipline, but also in translational aspectsof cancer research. The overall goal of the Career Development Program of this P50 has been toprovide broad multidisciplinary training for two junior investigators per year who have an outstandingacademic track record and who wish to change research directions and/or who need additional timein a productive scientific environment to establish an independent research program. The programemphasizes the education of basic (PhD) and clinical (MD or MD/PhD) scientists in the principles andapplications of molecular imaging techniques to answer basic science or clinical questions through invivo imaging. The program consists of multidisciplinary training by senior preceptors, didactic lecturesindividual research projects and design of hypothesis driven research, publication and grant writing.
The specific aims of the Program are:1. Recruit two outstanding junior faculty per year from a larger applicant pool2. Provide broad training and research support to the above individuals3. Promote excellence in science and medicine
| Dubach, J Matthew; Kim, Eunha; Yang, Katherine et al. (2017) Quantitating drug-target engagement in single cells in vitro and in vivo. Nat Chem Biol 13:168-173 |
| Vinegoni, Claudio; Fumene Feruglio, Paolo; Brand, Christian et al. (2017) Measurement of drug-target engagement in live cells by two-photon fluorescence anisotropy imaging. Nat Protoc 12:1472-1497 |
| Iaconelli, Jonathan; Lalonde, Jasmin; Watmuff, Bradley et al. (2017) Lysine Deacetylation by HDAC6 Regulates the Kinase Activity of AKT in Human Neural Progenitor Cells. ACS Chem Biol 12:2139-2148 |
| Arlauckas, Sean P; Garris, Christopher S; Kohler, Rainer H et al. (2017) In vivo imaging reveals a tumor-associated macrophage-mediated resistance pathway in anti-PD-1 therapy. Sci Transl Med 9: |
| Miller, Miles A; Weissleder, Ralph (2017) Imaging the pharmacology of nanomaterials by intravital microscopy: Toward understanding their biological behavior. Adv Drug Deliv Rev 113:61-86 |
| Engblom, Camilla; Pfirschke, Christina; Zilionis, Rapolas et al. (2017) Osteoblasts remotely supply lung tumors with cancer-promoting SiglecFhigh neutrophils. Science 358: |
| Miller, Miles A; Askevold, Bjorn; Mikula, Hannes et al. (2017) Nano-palladium is a cellular catalyst for in vivo chemistry. Nat Commun 8:15906 |
| Roy, Jeremy; Kim, Bongki; Hill, Eric et al. (2016) Tyrosine kinase-mediated axial motility of basal cells revealed by intravital imaging. Nat Commun 7:10666 |
| Pfirschke, Christina; Engblom, Camilla; Rickelt, Steffen et al. (2016) Immunogenic Chemotherapy Sensitizes Tumors to Checkpoint Blockade Therapy. Immunity 44:343-54 |
| Wu, Juwell W; Turcotte, Raphaël; Alt, Clemens et al. (2016) Defining Clonal Color in Fluorescent Multi-Clonal Tracking. Sci Rep 6:24303 |
Showing the most recent 10 out of 316 publications
