The ability to non-invasively map specific molecular, cellular and pathophysiologic information inmouse models and in xenotransplants will be critical to the success of the program. Specifically, imaging inlive animals will be essential in detecting early abnormalities during cancer initiation and progression, inestablishing imaging-phenotype correlations, in validating targets and linked biomarkers, and in assessingtherapeutic efficacy of therapeutic agents. The core serves two specific purposes: a) as a high-tech core andintellectual resource to perform and assist with imaging experiments and b) as an innovative research coreto further develop novel imaging approaches required in the different projects.The imaging technologies provided by the core range from microscopic to macroscopic resolutiontechniques, all highly optimized for mouse imaging. Specific imaging techniques include intravital confocalmicroscopy, fluorescence reflectance imaging, fiberoptic fluorescence imaging, fluorescence-mediatedtomography (FMT), bioluminescence imaging, single photon computed emission tomography (SPECT),positron emission tomography (PET), x-ray computed tomography (CT) and magnetic resonance imaging. Arecently developed web-based bioinformatics platform (CMIR-MIPortal ) will assure access to imagingstudies and enable refined combination and query of genomic/proteomic data with phenotypic or molecularimaging data. This system is one component of our web-based communication system that permits regularexchange of information among the P50 membership. The core will also act as a central conduit to ourcollaborators (Drs. dePinho and Jacks) to gain access to unique mouse models and in collaboration, validatethe use of novel imaging agent. Finally, the Core will assist with all experimental pathology studies to assurethe highest degree of expertise.
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