Abstract

The primary objective of the Biostatistics/Database Core is to provide centralized statistical services,collaborative research and data management support for the research projects of the Specialized ProgramofResearch Excellence (SPORE) for Breast Cancer. The Core will serve as the focal point from which SPOREinvestigators and career development candidates can draw statistical expertise for the design, datamanagement and analysis of their research projects.
The specific aims of the Core are to: 1) providestatistical expertise in study design, including endpoint definition, sample size estimation and powercalculation, randomization procedures, data collection form design, plans for report generation, interimreviews, and final analysis; 2) provide statistical analyses and informatics support for the SPORE projectsusing contemporary statistical and computing methodologies; and 3) provide data management support forthe development and management of a Breast SPORE Comprehensive Database, as well as project/Corespecific databases for the SPORE investigators. The Biostatistics/Database Core is based in the Biostatisticsand Bioinformatics Unit (BBU) of the UAB Comprehensive Cancer Center and derives its personnelmanagement, computing and other infrastructural support from the BBU. All projects and other cores of theSPORE will be supported by the Biostatistics/Database Core.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center (P50)
Project #
2P50CA089019-06A2
Application #
7290719
Study Section
Special Emphasis Panel (ZCA1-RPRB-M (O1))
Project Start
2007-07-01
Project End
2012-06-30
Budget Start
2007-09-25
Budget End
2008-08-31
Support Year
6
Fiscal Year
2007
Total Cost
$125,241
Indirect Cost

  Institution

Name
University of Alabama Birmingham
Department
Type
DUNS #
063690705
City
Birmingham
State
AL
Country
United States
Zip Code
35294

  Publications

Wielgos, Monica E; Zhang, Zhuo; Rajbhandari, Rajani et al. (2018) Trastuzumab-Resistant HER2+ Breast Cancer Cells Retain Sensitivity to Poly (ADP-Ribose) Polymerase (PARP) Inhibition. Mol Cancer Ther 17:921-930
Wielgos, Monica E; Rajbhandari, Rajani; Cooper, Tiffiny S et al. (2017) Let-7 Status Is Crucial for PARP1 Expression in HER2-Overexpressing Breast Tumors. Mol Cancer Res 15:340-347
Forero, Andres; Li, Yufeng; Chen, Dongquan et al. (2016) Expression of the MHC Class II Pathway in Triple-Negative Breast Cancer Tumor Cells Is Associated with a Good Prognosis and Infiltrating Lymphocytes. Cancer Immunol Res 4:390-9
McNally, Lacey R; Mezera, Megan; Morgan, Desiree E et al. (2016) Current and Emerging Clinical Applications of Multispectral Optoacoustic Tomography (MSOT) in Oncology. Clin Cancer Res 22:3432-9
Atherton, Daniel S; Sexton, Katherine C; Otali, Dennis et al. (2016) Factors Affecting the Use of Human Tissues in Biomedical Research: Implications in the Design and Operation of a Biorepository. Methods Mol Biol 1381:1-38
Li, Rong; Zhang, Kui; Penedo, Thuy Linh et al. (2016) The RANK Pathway in Advanced Breast Cancer: Does Src Play a Role? Appl Immunohistochem Mol Morphol 24:42-50
Walters, Beth; Thompson, Sunnie R (2016) Cap-Independent Translational Control of Carcinogenesis. Front Oncol 6:128
Wu, Lizhi; Chaudhary, Sandeep C; Atigadda, Venkatram R et al. (2016) Retinoid X Receptor Agonists Upregulate Genes Responsible for the Biosynthesis of All-Trans-Retinoic Acid in Human Epidermis. PLoS One 11:e0153556
Otali, D; Fredenburgh, J; Oelschlager, D K et al. (2016) A standard tissue as a control for histochemical and immunohistochemical staining. Biotech Histochem 91:309-26
Hoyt, Kenneth; Umphrey, Heidi; Lockhart, Mark et al. (2015) Ultrasound imaging of breast tumor perfusion and neovascular morphology. Ultrasound Med Biol 41:2292-302

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