Ductal carcinoma in situ (DCIS) is rising in incidence in American women. There is a growing appreciation that DCIS is a complex clinical entity with a highly variable natural history. At the same time, treatment options for women with DCIS have become more complicated. Despite the extensive literature on the psychosocial aspects of invasive breast cancer, there is little known about psychosocial outcomes, decision- making, and health behaviors of women with DCIS. This project will focus on psychosocial outcomes of women with DCIS, with the goal of developing interventions to improve psychosocial outcomes. Over a 3- month period, we will identify a total of 750 women with newly diagnosed DCIS from academic and community health care institutions. It is anticipated that 450 of these women will agree to participate in an observational study. Written questionnaires with follow-up telephone interviews will be used to assess anxiety, depression, risk perceptions, decision-making, use of complementary therapies, and other health behaviors. Women will be reassessed at nine and 18 months following diagnosis. In addition, physicians who provide care to the women in the study will complete a brief survey assessing their attitudes and management approaches to DCIS. The study will investigate the relationship between psychosocial outcomes, patient risk perceptions, clarity of treatment recommendations, and patient satisfaction with the decision-making process. The study also will assess the relationship between physicians' attitudes toward DCIS and patient risk perceptions and satisfaction with care. During the last 18 months of the five-year grant period, a psychosocial intervention will be developed and piloted, with the goal of improving psychosocial outcomes in these women.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center (P50)
Project #
1P50CA089393-01
Application #
6402285
Study Section
Special Emphasis Panel (ZCA1)
Project Start
2000-09-30
Project End
2005-09-29
Budget Start
Budget End
Support Year
1
Fiscal Year
2000
Total Cost
Indirect Cost
Name
Dana-Farber Cancer Institute
Department
Type
DUNS #
149617367
City
Boston
State
MA
Country
United States
Zip Code
02115
Kabraji, Sheheryar; Ni, Jing; Lin, Nancy U et al. (2018) Drug Resistance in HER2-Positive Breast Cancer Brain Metastases: Blame the Barrier or the Brain? Clin Cancer Res 24:1795-1804
Punglia, Rinaa S; Jiang, Wei; Lipsitz, Stuart R et al. (2018) Clinical risk score to predict likelihood of recurrence after ductal carcinoma in situ treated with breast-conserving surgery. Breast Cancer Res Treat 167:751-759
Liu, Hui; Murphy, Charles J; Karreth, Florian A et al. (2018) Identifying and Targeting Sporadic Oncogenic Genetic Aberrations in Mouse Models of Triple-Negative Breast Cancer. Cancer Discov 8:354-369
Asdourian, Maria S; Swaroop, Meyha N; Sayegh, Hoda E et al. (2017) Association Between Precautionary Behaviors and Breast Cancer-Related Lymphedema in Patients Undergoing Bilateral Surgery. J Clin Oncol 35:3934-3941
Sun, Fangdi; Skolny, Melissa N; Swaroop, Meyha N et al. (2016) The need for preoperative baseline arm measurement to accurately quantify breast cancer-related lymphedema. Breast Cancer Res Treat 157:229-240
Ferguson, Chantal M; Swaroop, Meyha N; Horick, Nora et al. (2016) Impact of Ipsilateral Blood Draws, Injections, Blood Pressure Measurements, and Air Travel on the Risk of Lymphedema for Patients Treated for Breast Cancer. J Clin Oncol 34:691-8
Miller, Cynthia L; Colwell, Amy S; Horick, Nora et al. (2016) Immediate Implant Reconstruction Is Associated With a Reduced Risk of Lymphedema Compared to Mastectomy Alone: A Prospective Cohort Study. Ann Surg 263:399-405
Sherr, Charles J; Beach, David; Shapiro, Geoffrey I (2016) Targeting CDK4 and CDK6: From Discovery to Therapy. Cancer Discov 6:353-67
Asdourian, Maria S; Skolny, Melissa N; Brunelle, Cheryl et al. (2016) Precautions for breast cancer-related lymphoedema: risk from air travel, ipsilateral arm blood pressure measurements, skin puncture, extreme temperatures, and cellulitis. Lancet Oncol 17:e392-405
Kochupurakkal, Bose S; Iglehart, J Dirk (2016) Identification of genes responsible for RelA-dependent proliferation arrest in human mammary epithelial cells conditionally expressing RelA. Genom Data 7:92-3

Showing the most recent 10 out of 291 publications