This Specialized Program of Research Excellence (SPORE) in prostate cancer at the Mayo Clinic Comprehensive Cancer Center will support a multidisciplinary team of basic, clinical, and population science investigators to perform translational research directed at significantly reducing mortality from prostate carcinoma. Donald J. Tindall, Ph.D. will serve as the Principal Investigator. Michael M. Liebet, M.D. will serve as Co-Principal Investigator. The translational research objectives of the SPORE will be directed by six research projects: Project 1: Genetic Susceptibility in Prostate Cancer (Stephen N. Thibodeau, Ph.D., Michael L. Blute, M.D., Daniel J. Schaid, Ph.D., James R. Cerhan: M.D., Ph.D., Steven J. Jacobsen, M.D., Ph.D.) Project 2: Human Kallikreins as Novel Markers of Prostate Cancer (Charles Y.F. Young, George G. Klee, M.D., Ph.D. Donald J. Tindall, Ph.D., Michael Liebet, M.D.). Project 3: Biologic and Clinical Studies of the Over-represented 8q24 Region Associated with Prostate Cancer Progression (Robert B. Jenkins, M.D., Ph.D., Michael M. Liebet, M.D.). Project 4: An Immune-Based Therapeutic Approach for Prostate Cancer, (Esteban Celis, M.D., Ph.D., Patrick A. Burch, M.D.,). Project 5: Use of Fusogeoic Membrane Glycoproteins for Gene Therapy of Prostate Cancer (Richard G. Vile, Ph.D., Evanthia Galahis, M.D., Brian J. Davis, M.D., Torrance Wilson, M.D.). Project 6: Gene Therapy of Prostate Cancer using Radioactive Iodine (John C. Morris III, M.D., Brian J. Davis, M.D., Esteban Celis, M.D., Richard G. Vile, Ph.D.). Five core resources will support these research projects: Core 1: Administrative Core (Donald J. Tindall, Ph.D.). Core 2: Prostate Cancer Tissue Resource Core (John C. Cheville, M.D., Patrick Roche, Ph.D.). Core 3: Gene Discovery and Bioinformatics Core (George Vasmatzis, Ph.D., Stephen J. Itturria, Ph.D.). Core 4: Clinical Follow-up Core (Brian J. Davis, M.D., Mike Blute M.D., Patrick A. Burch, M.D., Thomas M. Pisansky, M.D.). Core 5: Biostatistics Core (Daniel J. Sargent, Ph.D., Susan Geyer, Ph.D., Erik J. Bergstrahl, M.S.). A Developmental Research Program has been established to explore opportunities for innovative research and a Career Development Program has been organized to facilitate young investigators to establish independence in prostate cancer translational research. The SPORE structure provides the ideal mechanism to focus and integrate the discovery efforts of investigators and to optimally utilize the clinical resources of the Mayo Clinic practice to make meaningful advances in the management of prostate cancer.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center (P50)
Project #
5P50CA091956-05
Application #
6944014
Study Section
Special Emphasis Panel (ZCA1-GRB-V (M1))
Program Officer
Hruszkewycz, Andrew M
Project Start
2001-08-31
Project End
2006-08-31
Budget Start
2005-08-01
Budget End
2006-08-31
Support Year
5
Fiscal Year
2005
Total Cost
$2,555,905
Indirect Cost
Name
Mayo Clinic, Rochester
Department
Type
DUNS #
006471700
City
Rochester
State
MN
Country
United States
Zip Code
55905
Guerrico, Anatilde Gonzalez; Hillman, David; Karnes, Jeffery et al. (2017) Roles of kallikrein-2 biomarkers (free-hK2 and pro-hK2) for predicting prostate cancer progression-free survival. J Circ Biomark 6:1849454417720151
Hearn, Jason W D; AbuAli, Ghada; Reichard, Chad A et al. (2016) HSD3B1 and resistance to androgen-deprivation therapy in prostate cancer: a retrospective, multicohort study. Lancet Oncol 17:1435-1444
Spratt, Daniel E; Evans, Michael J; Davis, Brian J et al. (2015) Androgen Receptor Upregulation Mediates Radioresistance after Ionizing Radiation. Cancer Res 75:4688-96
Lu, Ji; Lonergan, Peter E; Nacusi, Lucas P et al. (2015) The cistrome and gene signature of androgen receptor splice variants in castration resistant prostate cancer cells. J Urol 193:690-8
Urban, Matthew W; Wang, Chenyi; Alizad, Azra et al. (2015) Complex background suppression for vibro-acoustography images. Ultrasonics 56:456-72
Cooperberg, Matthew R; Davicioni, Elai; Crisan, Anamaria et al. (2015) Combined value of validated clinical and genomic risk stratification tools for predicting prostate cancer mortality in a high-risk prostatectomy cohort. Eur Urol 67:326-33
Alshalalfa, Mohammed; Crisan, Anamaria; Vergara, Ismael A et al. (2015) Clinical and genomic analysis of metastatic prostate cancer progression with a background of postoperative biochemical recurrence. BJU Int 116:556-67
Loeb, Stacy; Sanda, Martin G; Broyles, Dennis L et al. (2015) The prostate health index selectively identifies clinically significant prostate cancer. J Urol 193:1163-9
Ahmed, Kamran A; Davis, Brian J; Mynderse, Lance A et al. (2014) Comparison of biochemical failure rates between permanent prostate brachytherapy and radical retropubic prostatectomy as a function of posttherapy PSA nadir plus 'X'. Radiat Oncol 9:171
Wu, Qiang; Kohli, Manish; Bergen 3rd, H Robert et al. (2014) Preclinical evaluation of the supercritical extract of azadirachta indica (neem) leaves in vitro and in vivo on inhibition of prostate cancer tumor growth. Mol Cancer Ther 13:1067-77

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