The purpose of the Biostatistics Core is to provide design and analytic support to SPORE Projects,Developmental Projects, and other Cores. This core has three specific aims.1. To provide biostatistical expertise for the planning, conduct, analysis, and reporting of laboratory, animal,clinical, and epidemiological studies for SPORE projects and developmental projects. The Biostatistics Corewill work with SPORE researchers on protocol and experimental design, and will provide estimates ofsample size and statistical power. The Core will advise researchers about optimal methods for monitoringongoing studies. The Core will provide statistical analyses of completed experiments, and participate inmanuscript preparation.2. To provide or recommend supporting computational infrastructure, including computer databases,statistical computer packages, publicly available statistical programs and data sharing between computers ordatabases. Because an effective informatics infrastructure is critical to the functioning of the SPORE, theBiostatistics Core will work to assure that the storage and accessibility of data used and generated by theSPORE is efficient and effective. The Biostatistics Core will support efficient management of data resourcesby consulting on database design, helping to design efficient data collection methods and conducting auditsof data quality.3: To provide consulting and statistical education to SPORE researchers. In addition to formal collaborativeefforts, the Biostatistics Core will be available for ongoing, informal consultation with researchers over theduration of the SPORE.In addition the Biostatistics Core will work with investigators within the DF/HCC Skin Cancer SPORE, otherSkin Cancer SPOREs and Cooperative Groups to attempt to build a prognostic and predictive model formelanoma patients with a web-based statistical product that will help physicians define the prognosis andselect the optimal therapy for individual patients with various stages of melanoma.
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