The Leadership and Administrative Core (LAC) will serve to integrate and enhance the research conducted by the Pacific Northwest Prostate SPORE Projects and Cores ? as well as faculty supported by the Career Enhancement and Developmental Research Programs ? through the application of general administrative support and the facilitation of communication and data dissemination. The Core will also provide formal links between the following entities: (1) All investigators comprising the Pacific Northwest (PNW) SPORE in prostate cancer; (2) Advisory Panels (e.g., External Advisory Board [EAB], Internal Advisory Board [IAB], etc.); (3) The institutions (e.g., FHCRC and other SPORE participatory sites) with laboratories and clinical facilities wherein occur the research and education components of the SPORE; and (4) Representatives of the National Cancer Institute (NCI). This Leadership and Administrative Core has the following Specific Aims:
Specific Aim 1 : To provide the organizational structure, based on a group of interacting committees, for supporting and evaluating the key objectives of the PNW SPORE.
Specific Aim 2 : To provide oversight of all SPORE activities involving the independent research projects, the Career Enhancement Program (CEP), the Developmental Research Program (DRP), the shared resource Cores, and the parent institutions.
Specific Aim 3 : To organize and coordinate forums for interactions of the Executive Committee, Internal Advisory Board, and External Advisory Board.
Specific Aim 4 : To provide efficient and effective fiscal management of SPORE grant funds.
Specific Aim 5 : To communicate and consult with the NCI Project Officer(s) and staff in the preparation of required progress reports, publications lists, and regulatory documents.
Specific Aim 6 : To develop and maintain virtual mechanisms that efficiently facilitate multi-institutional, intra- and inter-SPORE interactions.

Public Health Relevance

The ongoing, successful functioning of the PNW Prostate Cancer SPORE is highly-dependent upon the effective and efficient operations provided by the Leadership and Administrative Core. The Core is vital for carrying out the overall scientific and translational SPORE mission and will continue to be the hub for SPORE-related management, education, and communication within and across the four SPORE institutions.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center (P50)
Project #
5P50CA097186-18
Application #
10016179
Study Section
Special Emphasis Panel (ZCA1)
Project Start
2002-09-19
Project End
2023-08-31
Budget Start
2020-09-01
Budget End
2021-08-31
Support Year
18
Fiscal Year
2020
Total Cost
Indirect Cost
Name
Fred Hutchinson Cancer Research Center
Department
Type
DUNS #
078200995
City
Seattle
State
WA
Country
United States
Zip Code
98109
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Das, Lipsa; Gard, Jaime M C; Prekeris, Rytis et al. (2018) Novel Regulation of Integrin Trafficking by Rab11-FIP5 in Aggressive Prostate Cancer. Mol Cancer Res 16:1319-1331
Dai, James Y; Wang, Bo; Wang, Xiaoyu et al. (2018) Vigorous physical activity is associated with metastatic-lethal progression in prostate cancer and differential tumor DNA methylation in the CRACR2A gene. Cancer Epidemiol Biomarkers Prev :
Mateo, Joaquin; Cheng, Heather H; Beltran, Himisha et al. (2018) Clinical Outcome of Prostate Cancer Patients with Germline DNA Repair Mutations: Retrospective Analysis from an International Study. Eur Urol 73:687-693
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Sehrawat, Archana; Gao, Lina; Wang, Yuliang et al. (2018) LSD1 activates a lethal prostate cancer gene network independently of its demethylase function. Proc Natl Acad Sci U S A 115:E4179-E4188
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Lee, Chung C W; Munuganti, Ravi Shashi Nayana; Peacock, James W et al. (2018) Targeting Semaphorin 3C in Prostate Cancer With Small Molecules. J Endocr Soc 2:1381-1394
Mostaghel, Elahe A (2018) Alternative Acts: Oncogenic Splicing of Steroidogenic Enzymes in Prostate Cancer. Clin Cancer Res :
Zhao, Shanshan; Leonardson, Amy; Geybels, Milan S et al. (2018) A five-CpG DNA methylation score to predict metastatic-lethal outcomes in men treated with radical prostatectomy for localized prostate cancer. Prostate :

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