The overall goal of the Biostatistics/Bioinformatics Core (Core B) is to provide state-of-the-art biostatistics and bioinformatics support to ensure the rigor of the science and operations within the Cervical SPORE by participating fully in the design of preclinical studies and clinical trials, validation of assays and data systems, qualitycontrolofdataandspecimenmanagement,andthestatisticalanalysis,interpretation,presentationand sharingofdatabyconsultationandcollaborationthroughoutourinfrastructureattheJohnsHopkinsUniversity (JHU), University of Alabama at Birmingham (UAB), and the University of Colorado at Boulder. Core B will provide centralized biostatistical and bioinformatics services as well as collaborative research and data managementsupportfortheresearchprojectsoftheSPORE.CoreBwillserveasthefocalpointfromwhich theSPOREinvestigators,includingdevelopmentalpilotprojectandcareerenhancementprogramawardees,to draw upon statistical expertise for their research projects.
The Specific Aims of Core B are to (1) provide biostatisticsandbioinformaticsconsultationandsupportbyassistinginexperimentaldesignanddatacollection, visualization,analysis,quantitativemodeling,interpretation,andpublicationforallSPOREprojects;?(2)provide biostatistics and bioinformatics support for the Tissue/Pathology/Immunology Core (Core C), the Developmental Research Program (DEP) awardees, and the Career Enhancement Program (CEP) awardees;? and (3) to develop new or adapt existing biostatistics and bioinformatics methods as needed and appropriate.CoreBwillalsoprovideassistancewiththeidentificationandsolutionofcomplexdatabasetasks arisinginthecourseofprojectactivities.Thisincludesintegrationofclinicalandbasicresearchdatabasesand interfaces for data entry, data retrieval, patient or sample tracking, and procedures to ensure data quality, integrity, and confidentiality. This web-based database will provide a centralized means to produce interim reports of projected progress, patient accrual, processing of specimens, completeness of data gathering, and monitoringofpatientdropoutorlosstofollow-up.CoreBisledbyDrs.ChenguangWang,Ph.D.(JHU),Sejong Bae,Ph.D.(UAB),andAnneRositch,M.S.P.H.,Ph.D.(JHU),andfurthersupportedbyco-investigatorDr.Sarah Wheelan, M.D., Ph.D. (JHU). All projects, including those within the CEP and DRP, and other cores of the SPOREwillbesupportedbyCoreB.

Public Health Relevance

The Biostatistics/Bioinformatics Core (Core B) will provide state-of-the-art biostatistics and bioinformatics supporttoensuretherigorofthescienceandoperationswithintheCervicalSPOREbyparticipatingfullyinthe designofpreclinicalstudiesandclinicaltrials,validationofassaysanddatasystems,qualitycontrolofdataand specimen management, and the statistical analysis, interpretation, presentation and sharing of data by consultation and collaboration throughout our infrastructure at the Johns Hopkins University, University of AlabamaatBirmingham,andtheUniversityofColoradoatBoulder.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Specialized Center (P50)
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Special Emphasis Panel (ZCA1)
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Johns Hopkins University
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Boitano, Teresa K L; Smith, Haller J; Rushton, Tullia et al. (2018) Impact of enhanced recovery after surgery (ERAS) protocol on gastrointestinal function in gynecologic oncology patients undergoing laparotomy. Gynecol Oncol 151:282-286
Anchoori, Ravi K; Jiang, Rosie; Peng, Shiwen et al. (2018) Covalent Rpn13-Binding Inhibitors for the Treatment of Ovarian Cancer. ACS Omega 3:11917-11929
Ooki, Akira; Dinalankara, Wikum; Marchionni, Luigi et al. (2018) Epigenetically regulated PAX6 drives cancer cells toward a stem-like state via GLI-SOX2 signaling axis in lung adenocarcinoma. Oncogene 37:5967-5981
Ahn, Julie; Bishop, Justin A; Roden, Richard B S et al. (2018) The PD-1 and PD-L1 pathway in recurrent respiratory papillomatosis. Laryngoscope 128:E27-E32
Silver, Michelle I; Rositch, Anne F; Phelan-Emrick, Darcy F et al. (2018) Uptake of HPV testing and extended cervical cancer screening intervals following cytology alone and Pap/HPV cotesting in women aged 30-65 years. Cancer Causes Control 29:43-50
Yang, J-Ming; Bhattacharya, Sayak; West-Foyle, Hoku et al. (2018) Integrating chemical and mechanical signals through dynamic coupling between cellular protrusions and pulsed ERK activation. Nat Commun 9:4673
Xing, Deyin; Zheng, Gang; Schoolmeester, John Kenneth et al. (2018) Next-generation Sequencing Reveals Recurrent Somatic Mutations in Small Cell Neuroendocrine Carcinoma of the Uterine Cervix. Am J Surg Pathol 42:750-760
Qiu, Jin; Peng, Shiwen; Ma, Ying et al. (2018) Epithelial boost enhances antigen expression by vaccinia virus for the generation of potent CD8+ T cell-mediated antitumor immunity following DNA priming vaccination. Virology 525:205-215
Ooki, Akira; Begum, Asma; Marchionni, Luigi et al. (2018) Arsenic promotes the COX2/PGE2-SOX2 axis to increase the malignant stemness properties of urothelial cells. Int J Cancer 143:113-126
Leath 3rd, Charles A; Monk, Bradley J (2018) Twenty-first century cervical cancer management: A historical perspective of the gynecologic oncology group/NRG oncology over the past twenty years. Gynecol Oncol 150:391-397

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