The University of Texas M.D. Anderson Cancer Center is proposing a Specialized Program of ResearchExcellence (SPORE) in Leukemia. The primary goal of this Leukemia SPORE is to cultivate and facilitateinnovative and significant translational research in the biologic, genetic and clinical aspects of leukemia toimprove understanding, therapy, and prognosis. The multidisciplinary group of investigators in the LeukemiaSPORE will accomplish this goal through effective integration of laboratory, epidemiologic and clinicalinvestigations. The SPORE is designed with 5 research projects and 3 core resources, as well as programsfor developmental research and career development. The research projects are designed to target specificareas important in leukemia.Project 1 - Epigenetics and epigenetic therapy in AMLProject 2 - Adoptive Cellular Therapy for Myeloid LeukemiaProject 3 - p53 Activation as Novel Therapeutic Strategy for Acute Myelogenous LeukemiaProject 4 - Incorporating FLT3 inhibitors into AML treatment regimensProject 5 - Development of Sepacitabine Therapy in LeukemiasCore and other resources are:Core A - AdministrationCore B - Pathology and Tissue CoreCore C- Biostatistics and Data ManagementDevelopment Research Program and Career Development Program.Through this leukemia SPORE, our research team will make a significant impact on leukemia prognosis.Lay Abstract: This leukemia SPORE integrates clinical and basic investigations to introduce new therapiesin leukemia that are aimed at increasing the cure rate in this disease.
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