The Biostatistics Core (BC) provides statistical collaboration and data management support for each of theSPORE projects, the Developmental Research Program projects, the Career Development Program, and theother Cores. In the past funding period, the BC supported research, and established the infrastructure to linkthe Tissue and Patient Registry Cores. For this competitive renewal, the BC prepared the statistical plans foreach of the four Projects, will provide data management for each of the projects, and will prepare datasummaries for manuscript preparation. Each of the projects presented in this application reflects input frommembers of the BC on study design, and analysis plan. These projects span a wide range of approachesand analyses required. The BC builds upon the innovative and time-tested procedures and systemsdeveloped by Mayo Clinic, one of the largest statistical groups in the country whose members havecollaborated on more than 10,000 clinical and basic science research studies since 1966. The BC hascapability to provide statistical support across different fields, including molecular epidemiologic studies,basic science with translational, immunologic, and correlative studies, gene microarray and imaging, clinicaltrials, gene and mutation discovery, and information management. The comprehensive nature of the BCassures each SPORE investigator access to statistical expertise that includes collaborative development ofstudy designs and analysis plans, state-of-the-art data analysis and interpretation, data managementresources, and abstract and manuscript preparation. The BC also provides a mechanism for themanagement and integration of both existing and newly collected data through consistent and compatibledata handling. Areas of support include database development, data form development and processing, datacollection and entry, data archiving, quality control, and management of information relating to the projectsand cores. This Core complements and assists the efforts of the Clinical Research and Tissue Cores byproviding superior data management and experience with tissue registries. The strengths of the BC are ourcollaboration with each of the projects and cores, the ability to utilize the established centralized researchdatabase, the operational and statistical infrastructure already in place in the SPORE, and the breadth ofexpertise provided by BC personnel.
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