The purpose of this resource is to provide tissue, cells and pathology services to all 5 research projects andcareer or research development awardees covered by this application. The plan for this Lymphoma SPOREis to combine pathology resources of the Dan L Duncan Cancer Center at Baylor College of Medicine (BCM)and its affiliated institutions with those of The Methodist Hospital to ensure adequate numbers and timelydelivery of tissue/cell samples for the projected needs of project investigators. It will therefore co-ordinateacquisition of tissue for banking from lymphoma and CLL patients at 5 affiliated hospitals in the TexasMedical Center, by relying on tissue collection and distribution systems already in place. The capacity toobtain samples from 5 affiliated hospitals will greatly increase the number of specimens we are able toanalyze, store and distribute. The core will also provide pathology services including routine tissuepreparation, immunohistochemical staining, laser capture microdissection, preparation of tissue microarrays,flow cytometry, detection of minimal residual disease and in situ hybridization for viral RNAs. These tasksare essential to the successful completion of planned experiments in each project and will be performed byexpert pathologists and histotechnologists with substantial experience in providing core services to SPOREinvestigators. We believe the resultant Tissue Core will have the necessary laboratory space, equipment andhuman resources to handle the workload outlined for the Lymphoma SPORE. This core also containsbioinformatics support to support tissue-banking software needs for the lymphoma core and includesinvestigators with expertise in developing CDEs and experience working with the BCM Prostate SPOREs todevelop a caBIG compliant system linking biospecimen data.
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