All projects in this SPORE will use human specimens for translational research directed at reducing theincidence and mortality of pancreatic cancer. In order to provide the necessary specimens, a PancreasTumor SPORE Tissue Bank has been developed in cooperation with and under the auspices of theUniversity of Nebraska Medical Center (UNMC) Tumor Bank. There are two components to this resource.The first component is a conventional tissue bank, which captures and stores all excess surgical materialfrom patients seen at UNMC and affiliated institutions, related to pancreatic and Gl malignancies. Thistissue bank also captures and stores samples related to clinical trials that are ongoing as part of SPOREactivites. The second component is an organ harvest/rapid autopsy program in which patients who die withpancreatic cancer donate their organs for research purposes. This program captures and processes entireinternal organs from these patients, including all available samples of primary tumor and metastases.Theguidelines and protocols for collecting specimens established by the UNMC Tumor Bank and the InstitutionalReview Board are followed for the SPORE proposal. This core facility stores normal, benign (i.e. acuteand/or chronic fibrosing pancreatitis) and malignant pancreatic tissues (including both primary and metastaticpancreatic carcinomas) and peripheral blood lymphocytes, plasma and serum from patients with pancreaticmalignancies. The Bank also coordinates collection and storage of pancreatic ductal secretions andperitoneal washings. Cytogenetic analysis is performed on malignant lesions when possible. The coreincludes a mechanism for database management and specimen distribution. A uniform system ofprioritization of requested materials has been defined and used by the Pancreas Tumor SPORE Tissue BankOversight Committee. This core facility is intended to benefit the specific research activities of the SPORE,as well as the research activities of other scientists within and outside of UNMC who are concentrating ontranslational research issues. Additionally, tissues are available for distribution through NCI supported tissuenetworks in national prioritization. Only specimens obtained from clinically indicated surgeries after all otherdiagnostic procedures have been performed are submitted to the Pancreas Tumor SPORE Tissue Bank fortranslational research. The specimens would otherwise be discarded or disposed of. Eligible patients havethe opportunity to participate by submitting written informed consent. There is no risk to the patient orcompromise to the patient's care, since all of the procedures performed would be performed for diagnosticreasons regardless of the SPORE. Members of the pathology department and the clinical departments areparticipants in the individual research projects and thus, also contribute to the Core for maximal and effectiveaccumulation of satisfactory specimens.
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