The purpose of the Biostatistics, Modeling, and Data Management Core (Core C) is to provide acomprehensive, multi-disciplinary resource for the design of all experiments, development ofappropriate and innovative statistical methodology, development and application of appropriate kineticmodels to intrepret the data, statistical analysis, and summarization of results. The Core has thefollowing overall goals: to provide statistical and modeling consulting and collaboration on the design,conduct, analysis and interpretation of all project research studies and cores, and to provide, manageand maintain a high-quality research database that supports the research projects and cores whilepreserving the confidentiality of all subject data.
The specific aims are to: (1) Coordinate and managestatistical activities to ensure investigators have ready access to statistical consultation and support.(2) Provide statistical expertise in the design of experiments and studies, including research proposaldevelopment, analysis methods, sample size determination, randomization procedures, and plans forinterim reviews and final analysis. (3) Provide kinetic modeling expertice for all projects using imagingto measure physiologic parameters. (4) Provide data analysis and extraction to obtain the necessaryinformation from project data. (5) Assist with the writing of statistical and modeling components ofmanuscripts. (6) Review the integrity and statistical soundness of all studies. (7) Maintain acomputing facility with up-to-date software for statistical analysis to support all project investigators.(8) Conduct biostatistical methodology research on practical problems arising from performance of theprojects. (9) Develop new modeling approaches as necessary to maximize the utility of eachinvestigator's data. (10) Provide computer-based tools that facilitate the storage and retrieval of thedata generated in the proposed research, thereby creating and maintaining a centralized relationaldatabase that provides access to common resources and information. (11) Ensure the accuracy of thedata maintained in the database by software based data consistency and quality control systems. (12)Organize and maintain the database to maximize accuracy and accessibility while maintaining strictconfidentiality. (13) Provide detailed descriptions of the available populations and resources for currentand future investigators. (14) Provide high-quality data entry services.
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