This proposal focuses on understanding the relationship between dietary patterns and risk of obesity in Hispanic women. This is an important issue in the realm of health disparities because neariy 80% of Hispanic women in the United States are ovenweight or obese and obesity increases risk for numerous chronic diseases, including breast cancer. The overall goal of this project Is to test the metabolic response to Western -and Indigenous Mexican diets in Hispanic women. We will also investigate whether ancestral genetic variation mediates the response to each diet. We hypothesize that the biological response to a Western dietary pattern produces detrimental metabolic profiles favoring adipose deposition, which leads to increased risk of adverse health events, including increased risk of breast cancer. Conversely, we hypothesize that the physiologic response to an Indigenous Mexican diet will produce a favorable metabolic profile. We further hypothesize that genetic ancestry mediates this biological response to a Western dietary pattern. Our primary aims are: (1) To test in a randomized cross-over experimental feeding study the metabolic response to an Indigenous Mexican diet vs. a Western diet in 50 first and second generation Hispanic women living in the greater Seattle area. The metabolic response will be measured by blood concentrations ofthe following biomarkers assessed before and after each feeding period: insulin, glucose, IGFI, IGFBP3, leptin, adiponectin, IL-6, CRP and SAA; and (2) To investigate whether genetic characteristics, as assessed with Ancestry Informative Markers, mediate the metabolic response to each tested diet. As secondary alms we will examine measures of hunger and satiety during each diet test period and genetic predictors of adiposity. This project will provide important data for understanding the etiology of obesity in i-lispanic women, which can be used to design effective programs for prevention.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center (P50)
Project #
3P50CA148143-05S1
Application #
9269315
Study Section
Special Emphasis Panel (ZCA1)
Program Officer
Srinivasan, Shobha
Project Start
Project End
Budget Start
2014-05-01
Budget End
2017-04-30
Support Year
5
Fiscal Year
2016
Total Cost
Indirect Cost
Name
Fred Hutchinson Cancer Research Center
Department
Type
DUNS #
078200995
City
Seattle
State
WA
Country
United States
Zip Code
98109
Scheel, John R; Tillack, Allison A; Mercer, Lauren et al. (2018) Mobile Versus Fixed Facility: Latinas' Attitudes and Preferences for Obtaining a Mammogram. J Am Coll Radiol 15:19-28
Baglia, Michelle L; Cook, Linda S; Mei-Tzu, C et al. (2018) Alcohol, smoking, and risk of Her2-overexpressing and triple-negative breast cancer relative to estrogen receptor-positive breast cancer. Int J Cancer 143:1849-1857
Glassgow, Anne Elizabeth; Molina, Yamile; Kim, Sage et al. (2018) A Comparison of Different Intensities of Patient Navigation After Abnormal Mammography. Health Promot Pract :1524839918782168
Molina, Yamile; Kim, Sage J; Berrios, Nerida et al. (2018) Patient Navigation Improves Subsequent Breast Cancer Screening After a Noncancerous Result: Evidence from the Patient Navigation in Medically Underserved Areas Study. J Womens Health (Larchmt) 27:317-323
Molina, Yamile; Beresford, Shirley A A; Thompson, Beti (2017) Psychological Outcomes After a False Positive Mammogram: Preliminary Evidence for Ethnic Differences Across Time. J Racial Ethn Health Disparities 4:123-133
Molina, Yamile; Beresford, Shirley A A; Hayes Constant, Tara et al. (2017) Conversations about Abnormal Mammograms on Distress and Timely Follow-up Across Ethnicity. J Cancer Educ 32:320-327
Molina, Yamile; Plascak, Jesse J; Patrick, Donald L et al. (2017) Neighborhood Predictors of Mammography Barriers Among US-Based Latinas. J Racial Ethn Health Disparities 4:233-242
Thompson, Beti; Carosso, Elizabeth A; Jhingan, Esther et al. (2017) Results of a randomized controlled trial to increase cervical cancer screening among rural Latinas. Cancer 123:666-674
Molina, Yamile; Dirkes, Jessica; Ramirez-Valles, Jesus (2017) Burnout in HIV/AIDS Volunteers: A Socio-Cultural Analysis among Latino Gay, Bisexual Men, and Transgender People. Nonprofit Volunt Sect Q 46:1231-1249
Scheel, John R; Molina, Yamile; Coronado, Gloria et al. (2017) Healthcare Factors for Obtaining a Mammogram in Latinas With a Variable Mammography History. Oncol Nurs Forum 44:66-76

Showing the most recent 10 out of 54 publications