The Administrative Core will provide centralized thyroid cancer SPORE administration, communication processing, and budget management. This Core will also serve to amalgamate the investigators, their experimental findings and their ideas, evaluation of research efforts and direct the summary efforts toward the SPORE outcome.
The Specific Aims of the Administrative Core are to: 1. Provide administrative and leadership efforts for investigators. This includes the management of SPORE resources, development of support memos, and communications covering all operations. This Core will provide investigators with clear lines of scientific and administrative communication to promote collaboration among team members, aid in the prioritization of resources, facilitate communications with NCI, and facilitate timely resolution of SPORE issues. 2. Organize monthly meetings of the SPORE Steering Committee. This Steering committee shall consist of the Project Leaders, Core Directors, CDP and DRP Leaders. 3. Organize an annual SPORE scientific and administrative meeting to include an Internal and External Advisory Board meeting where a panel of experts shall assess the SPORE effectiveness and experimental progress, research directions, technical approaches, statistical evaluation, and administrative effectiveness. 4. Organize monthly SPORE Journal Club and scientific meetings for all members of the SPORE and their laboratory members. 5. Maintain integration activities that include data sharing through meetings and by maintaining a shared firewall-protected data sharing website, rapid publication efforts, and identification &institution of other novel activities critical to maintaining and strengthening the translational aspects of the thyroid cancer SPORE as the program develops information and new results. 6. Provide overall fiscal review, accounting, and real time budgets analyses. Conduct and direct the budget analysis including both descriptive summary expenditures and real time tracking of individual budgets. Provide fon/vard-looking projections on expenditures. These can be correlated with SPORE progress to provide superior SPORE management.
The Administrative Core is essential for the functions of the SPORE as an engine for investigating the genetic and molecular basis for thyroid cancer and for translating these discoveries into new therapies for these diseases.
|Bagheri-Yarmand, Rozita; Sinha, Krishna M; Li, Ling et al. (2018) Combinations of Tyrosine Kinase Inhibitor and ERAD Inhibitor Promote Oxidative Stress-Induced Apoptosis through ATF4 and KLF9 in Medullary Thyroid Cancer. Mol Cancer Res :|
|Puli, Oorvashi Roy; Danysh, Brian P; McBeath, Elena et al. (2018) The Transcription Factor ETV5 Mediates BRAFV600E-Induced Proliferation and TWIST1 Expression in Papillary Thyroid Cancer Cells. Neoplasia 20:1121-1134|
|Abrams, Zachary B; Zucker, Mark; Wang, Min et al. (2018) Thirty biologically interpretable clusters of transcription factors distinguish cancer type. BMC Genomics 19:738|
|Shu, Yi; Yin, Hongran; Rajabi, Mehdi et al. (2018) RNA-based micelles: A novel platform for paclitaxel loading and delivery. J Control Release 276:17-29|
|He, Huiling; Li, Wei; Liyanarachchi, Sandya et al. (2018) The Role of NRG1 in the Predisposition to Papillary Thyroid Carcinoma. J Clin Endocrinol Metab 103:1369-1379|
|Chakedis, Jeffery; Shirley, Lawrence A; Terando, Alicia M et al. (2018) Identification of the Thoracic Duct Using Indocyanine Green During Cervical Lymphadenectomy. Ann Surg Oncol 25:3711-3717|
|Xu, Congcong; Haque, Farzin; Jasinski, Daniel L et al. (2018) Favorable biodistribution, specific targeting and conditional endosomal escape of RNA nanoparticles in cancer therapy. Cancer Lett 414:57-70|
|Segkos, Konstantinos; Porter, Kyle; Senter, Leigha et al. (2018) Neck Ultrasound in Patients with Follicular Thyroid Carcinoma. Horm Cancer 9:433-439|
|Wang, Yanqiang; He, Huiling; Liyanarachchi, Sandya et al. (2018) The role of SMAD3 in the genetic predisposition to papillary thyroid carcinoma. Genet Med 20:927-935|
|Valenciaga, Anisley; Saji, Motoyasu; Yu, Lianbo et al. (2018) Transcriptional targeting of oncogene addiction in medullary thyroid cancer. JCI Insight 3:|
Showing the most recent 10 out of 50 publications