The overarching theme of this Tobacco Center of Regulatory Science is the development of improved models to inform tobacco product regulatory strategies that integrate 1) economic impacts of tobacco use on health costs, 2) risk perceptions, perceived acceptability, consumer responses to pro-tobacco marketing and anti-tobacco messages and other social determinants of tobacco use, and 3) rapid changes in risk due to tobacco use and secondhand smoke exposure as manifested in cardiovascular and pulmonary dysfunction. This TCORS includes five full projects (one on economic models, two on behavioral models, and two on cardiovascular and pulmonary disease models), two developmental projects (one on behavioral models and one on cardiovascular and pulmonary disease models), three Cores (Administrative, Informatics and Analysis, and Biomarker), a postdoctoral training program and a process for selecting future developmental projects. The results will inform FDA regulation of the manufacture, distribution and marketing of tobacco products by providing an improved scientific framework in which to evaluate the likely effects of specific regulatory strategies by developing 1) improved economic models for analysis of proposed regulations that account for short-term as well as long-term effects of tobacco use, 2) better understanding of behavioral and social determinants of tobacco use (including perception of risk and decision making processes) to inform the economic models, regulation of marketing, and public education about risks of tobacco products, and 3) functional biomarkers of acute cardiopulmonary responses to tobacco use and secondhand smoke that may predict future disease and also support development of improved economic models. In particular, these improved economic models will integrate the rapid changes in risk due to reductions in cardiovascular and pulmonary diseases which would be expected to result from FDA regulatory decisions. This TCORS is built on the UCSF Center for Tobacco Control Research and Education's tradition of strong transdisciplinary and collaborative research, education and service.

Public Health Relevance

This TCORS will inform FDA regulation by developing new economic models that account for short-term and long-term effects of tobacco use, developing a better understanding of behavioral determinants of tobacco use, and identifying functional biomarkers of acute cardiopulmonary responses to tobacco use that could be used in premarket testing of tobacco products.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center (P50)
Project #
5P50CA180890-02
Application #
8737818
Study Section
Special Emphasis Panel (ZRG1-BDCN-A (40))
Program Officer
Land, Stephanie R
Project Start
2013-09-19
Project End
2018-08-31
Budget Start
2014-09-01
Budget End
2015-08-31
Support Year
2
Fiscal Year
2014
Total Cost
$3,999,769
Indirect Cost
$1,464,056
Name
University of California San Francisco
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Glantz, Stanton A (2018) PMI's own in vivo clinical data on biomarkers of potential harm in Americans show that IQOS is not detectably different from conventional cigarettes. Tob Control 27:s9-s12
St Helen, Gideon; Shahid, Marian; Chu, Sherman et al. (2018) Impact of e-liquid flavors on e-cigarette vaping behavior. Drug Alcohol Depend 189:42-48
Ghosh, Arunava; Coakley, Raymond C; Mascenik, Teresa et al. (2018) Chronic E-Cigarette Exposure Alters the Human Bronchial Epithelial Proteome. Am J Respir Crit Care Med 198:67-76
Yao, Tingting; Sung, Hai-Yen; Wang, Yingning et al. (2018) Healthcare Costs of Secondhand Smoke Exposure at Home for U.S. Children. Am J Prev Med :
Glantz, Stanton A (2018) Heated tobacco products: the example of IQOS. Tob Control 27:s1-s6
McKelvey, Karma; Popova, Lucy; Kim, Minji et al. (2018) IQOS labelling will mislead consumers. Tob Control 27:s48-s54
Alzahrani, Talal; Pena, Ivan; Temesgen, Nardos et al. (2018) Association Between Electronic Cigarette Use and Myocardial Infarction. Am J Prev Med 55:455-461
Popova, Lucy; Thrul, Johannes; Glantz, Stanton A (2018) Effects of Large Cigarette Warning Labels on Smokers' Expected Longevity. Am J Health Behav 42:85-92
Lempert, Lauren Kass; Glantz, Stanton A (2018) Heated tobacco product regulation under US law and the FCTC. Tob Control 27:s118-s125
Halpern-Felsher, Bonnie; Kim, Hyoshin (2018) Measuring E-cigarette use, dependence, and perceptions: Important principles and considerations to advance tobacco regulatory science. Addict Behav 79:201-202

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