The Methods Core (MC) will provide centralized services to address research questions and issues pertaining to study design, measurement, analysis, and methods training to the TCORS research projects, other cores, and investigators. The MC will assure that measurement and data collection approaches are refined to be useful in various vulnerable populations and will also pro-actively refine and adapt data collection tools for use in diverse vulnerable populations, providing an internal service and one that will be of value to the other TCORS. The MC will offer services and consultation on identification, development and validation of instruments, and provision of state-of-the-art, culturally appropriate interview, physiological, psychosocial, behavioral community-based, archival, GIS, and observational measures, data management, statistical analysis, training and methodological and statistical consultation. The MC will maintain a web- based system to provide a central repository for data and facilitate instrument and file sharing among Center investigators, regulatory science trainees, and other funded TCORS. The MC core members bring expertise in discipline-specific measurement, design, and analytic techniques, such as advanced methodologies, statistical modeling, psychometrics analysis, qualitative data analysis, community-based participatory research (CBPR) methods, and behavioral data collection.
The Specific Aims of the Methods Core are: Design and Sampling. To assist in the review of research design protocols and to develop and implement appropriate sampling methodology for center studies and cores and to advise the Population Core on procedures for maximizing participation and tracking rates and minimizing attrition. Measurement Validation and Development. To assist in the identification of existing measures and development and validation of new measures that can be applied across projects. Data Management. To develop and maintain a website to serve as a centralized, secure web system to facilitate sharing of instruments and data sets across projects, conduct data entry for the projects. Data Analysis. To provide statistical and computer support for USC TCORS projects and regulatory science trainees, and to share new statistical methods with other TCORSs. Consultation, Training and Integration. To provide consulting to investigators and staff in measurement and analysis strategies, and collaborate in training in regulatory science methodologies with the Research Training and Education Core.

Public Health Relevance

The Methods Core coordinates existing resources, procedures and expertise to make them available to all the investigators in the center, and provides guidance to all studies on study design, statistical analysis, and measurement development. The Methods Core will help to assure that the research of the USC TCORS is as informative as possible.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Specialized Center (P50)
Project #
Application #
Study Section
Special Emphasis Panel (ZRG1-BDCN-A)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Southern California
Los Angeles
United States
Zip Code
Lienemann, Brianna A; Rose, Shyanika W; Unger, Jennifer B et al. (2018) Tobacco Advertisement Liking, Vulnerability Factors, and Tobacco Use among Young Adults. Nicotine Tob Res :
Goldenson, Nicholas I; Khoddam, Rubin; Stone, Matthew D et al. (2018) Associations of ADHD Symptoms With Smoking and Alternative Tobacco Product Use Initiation During Adolescence. J Pediatr Psychol 43:613-624
Camenga, D R; Fiellin, L E; Pendergrass, T et al. (2018) Adolescents' perceptions of flavored tobacco products, including E-cigarettes: A qualitative study to inform FDA tobacco education efforts through videogames. Addict Behav 82:189-194
Allem, Jon-Patrick; Dharmapuri, Likhit; Unger, Jennifer B et al. (2018) Characterizing JUUL-related posts on Twitter. Drug Alcohol Depend 190:1-5
Rose, Shyanika W; Glasser, Allison M; Zhou, Yitong et al. (2018) Adolescent tobacco coupon receipt, vulnerability characteristics and subsequent tobacco use: analysis of PATH Study, Waves 1 and 2. Tob Control 27:e50-e56
Morean, Meghan; Krishnan-Sarin, Suchitra; Sussman, Steve et al. (2018) Psychometric evaluation of the Patient-Reported Outcomes Measurement Information System (PROMIS) Nicotine Dependence Item Bank for use with electronic cigarettes. Nicotine Tob Res :
Barrington-Trimis, Jessica L; Gibson, Laura A; Halpern-Felsher, Bonnie et al. (2018) Type of E-Cigarette Device Used Among Adolescents and Young Adults: Findings From a Pooled Analysis of Eight Studies of 2166 Vapers. Nicotine Tob Res 20:271-274
Cruz, Tess Boley; McConnell, Rob; Low, Brittany Wagman et al. (2018) Tobacco Marketing and Subsequent Use of Cigarettes, E-cigarettes and Hookah in Adolescents. Nicotine Tob Res :
Hong, Hanna; McConnell, Rob; Liu, Fei et al. (2018) The impact of local regulation on reasons for electronic cigarette use among Southern California young adults. Addict Behav :
Gaalema, Diann E; Leventhal, Adam M; Priest, Jeffrey S et al. (2018) Understanding individual differences in vulnerability to cigarette smoking is enhanced by attention to the intersection of common risk factors. Prev Med 117:38-42

Showing the most recent 10 out of 93 publications