The purpose of this Career Enhancement Program is to support promising investigators who will participate in translational breast cancer research projects. There are one to two awardees at any one time, who may be either MD's or PhD's. Candidates are selected based on their previous accomplishments and their potential and desire to pursue a career in academic breast cancer research. While our primary focus is to support promising young investigators at the junior faculty level, it is possible that more established investigators may also be appropriate for support. The general outline of each awardee?s research will have been discussed by the applicant and the Selection Committee as a part of the selection process, and a principal mentor from the Program Faculty will be agreed upon. Awardees will receive further guidance from the Executive Committee and the selected mentor in developing their translational research projects throughout the award period. They will also participate in an extensive set of seminars, professional development courses, and clinical opportunities. The research environment at the Baylor Breast Center is ideal for supporting translational activities. Scientific excellence in breast cancer research continues to be reaffirmed by the award of both individual and collaborative grants, while both national and local programs of clinical investigation are well established at the Baylor Breast Center and can serve to assist in the translation of research findings into clinical practice. This is an excellent setting for enhancing and focusing the careers of outstanding investigators on productive translational research in breast cancer. Indeed, of the 21 young investigators who received partial support from this program in the 26 years since our first SPORE award, most are active in academic research positions in breast cancer, and four have important roles in this new SPORE proposal including one project leader.
The central goal of our translational research is to get the most up to date laboratory research and the most current clinical experience to talk productively to each other, for the most rapid and efficient progress toward controlling and eliminating breast cancer. Thus we have designed this career enhancement program to expose young researchers to the full range of the breast cancer research experience in a vigorously translational environment, whatever their initial training was, as they move towards research independence.
|Zhao, Na; Cao, Jin; Xu, Longyong et al. (2018) Pharmacological targeting of MYC-regulated IRE1/XBP1 pathway suppresses MYC-driven breast cancer. J Clin Invest 128:1283-1299|
|Bhat, Raksha R; Yadav, Puja; Sahay, Debashish et al. (2018) GPCRs profiling and identification of GPR110 as a potential new target in HER2+ breast cancer. Breast Cancer Res Treat 170:279-292|
|Guarducci, Cristina; Bonechi, Martina; Benelli, Matteo et al. (2018) Cyclin E1 and Rb modulation as common events at time of resistance to palbociclib in hormone receptor-positive breast cancer. NPJ Breast Cancer 4:38|
|Johnston, A N; Bu, W; Hein, S et al. (2018) Hyperprolactinemia-inducing antipsychotics increase breast cancer risk by activating JAK-STAT5 in precancerous lesions. Breast Cancer Res 20:42|
|Dasgupta, Subhamoy; Rajapakshe, Kimal; Zhu, Bokai et al. (2018) Metabolic enzyme PFKFB4 activates transcriptional coactivator SRC-3 to drive breast cancer. Nature 556:249-254|
|Rimawi, Mothaffar F; De Angelis, Carmine; Contreras, Alejandro et al. (2018) Low PTEN levels and PIK3CA mutations predict resistance to neoadjuvant lapatinib and trastuzumab without chemotherapy in patients with HER2 over-expressing breast cancer. Breast Cancer Res Treat 167:731-740|
|Bajgain, Pradip; Tawinwung, Supannikar; D'Elia, Lindsey et al. (2018) CAR T cell therapy for breast cancer: harnessing the tumor milieu to drive T cell activation. J Immunother Cancer 6:34|
|Niravath, Polly; Chen, Bingshu; Chapman, Judy-Anne W et al. (2018) Vitamin D Levels, Vitamin D Receptor Polymorphisms, and Inflammatory Cytokines in Aromatase Inhibitor-Induced Arthralgias: An Analysis of CCTG MA.27. Clin Breast Cancer 18:78-87|
|Hertz, D L; Kidwell, K M; Hilsenbeck, S G et al. (2017) CYP2D6 genotype is not associated with survival in breast cancer patients treated with tamoxifen: results from a population-based study. Breast Cancer Res Treat 166:277-287|
|Yu, L; Liang, Y; Cao, X et al. (2017) Identification of MYST3 as a novel epigenetic activator of ER? frequently amplified in breast cancer. Oncogene 36:2910-2918|
Showing the most recent 10 out of 28 publications